Özcan Ruhan Karahan, Özmen Selen Gür
Department of Neurology, Gebze Fatih Community Hospital, Kocaeli, Turkey.
Department of Neuroscience, Graduate School of Health Sciences, Bahcesehir University, Istanbul, Turkey.
Sisli Etfal Hastan Tip Bul. 2019 Nov 20;53(4):395-402. doi: 10.14744/SEMB.2018.09582. eCollection 2019.
The aim of this study was to examine the relationship between migraines and obesity, insulin resistance (IR), and metabolic syndrome in female migraineurs.
A total of 141 female patients who experience migraines and a control group of 141 sex- and age-matched individuals who do not were enrolled in this case-control study. The migraine group was composed of patients from the Gebze Fatih Community Hospital (Kocaeli, Turkey) neurology outpatient service and the control group included hospital staff and friends who volunteered to participate. Descriptive statistics and multivariate logistic regression analyses were performed. Migraine was designated as a dependent variable. Family history of migraine, stroke, metabolic syndrome, cardiac disease, hypertension, hyperlipidemia, and diabetes mellitus; cigarette use; alcohol consumption; and the presence of hypertension, IR, hypertriglyceridemia, low level of high-density lipoprotein (HDL), central obesity, metabolic syndrome; as well as homeostasis model assessment and quantitative insulin sensitivity check index results were selected as independent variables.
The mean waist circumference, mean height, mean weight, and central obesity were greater in the control group (p=0.009, 0.004, 0.036, and 0.015, respectively). A multivariate logistic regression model of migraine presence showed that a family history of migraine (odds ratio [OR]: 1.542, 95% confidence interval [CI]: 2.451-8.905; p<0.0001), family history of stroke (OR: 1.043, 95% CI: 1.214-6.633; p=0.016), and no central obesity (OR: -0.705, 95% CI: -0.290-0.843; p=0.010) were statistically significant variables in our study.
The results of our study indicated that IR and metabolic syndrome were not associated with migraine in women. There was an inverse relationship between central obesity and migraine. Additional research with larger participant groups should be performed to further explore the complex relationship between migraine, obesity, IR, and metabolic syndrome.
本研究旨在探讨女性偏头痛患者偏头痛与肥胖、胰岛素抵抗（IR）及代谢综合征之间的关系。
本病例对照研究共纳入141名有偏头痛经历的女性患者以及141名年龄和性别匹配的无偏头痛的对照个体。偏头痛组由来自土耳其科贾埃利盖布泽法提赫社区医院神经内科门诊的患者组成，对照组包括自愿参与的医院工作人员和朋友。进行了描述性统计和多因素逻辑回归分析。将偏头痛指定为因变量。偏头痛、中风、代谢综合征、心脏病、高血压、高脂血症和糖尿病的家族史；吸烟情况；饮酒情况；以及高血压、IR、高甘油三酯血症、高密度脂蛋白（HDL）水平低、中心性肥胖、代谢综合征的存在情况；以及稳态模型评估和定量胰岛素敏感性检查指数结果被选为自变量。
对照组的平均腰围、平均身高、平均体重和中心性肥胖更高（分别为p = 0.009、0.004、0.036和0.015）。偏头痛存在情况的多因素逻辑回归模型显示，偏头痛家族史（比值比[OR]：1.542，95%置信区间[CI]：2.451 - 8.905；p < 0.0001）、中风家族史（OR：1.043，95% CI：1.214 - 6.633；p = 0.016）以及无中心性肥胖（OR： - 0.705，95% CI： - 0.290 - 0.843；p = 0.010）是我们研究中有统计学意义的变量。
我们的研究结果表明，IR和代谢综合征与女性偏头痛无关。中心性肥胖与偏头痛之间存在负相关关系。应进行更大样本量的进一步研究，以进一步探索偏头痛、肥胖、IR和代谢综合征之间的复杂关系。
