基于结构重排技术的定向基因组进化。
Directed genome evolution driven by structural rearrangement techniques.
机构信息
Frontier Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, 300072, China.
Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
出版信息
Chem Soc Rev. 2021 Nov 15;50(22):12788-12807. doi: 10.1039/d1cs00722j.
Directed genome evolution simulates the process of natural evolution at the genomic level in the laboratory to generate desired phenotypes. Here we review the applications of recent technological advances in genome writing and editing to directed genome evolution, with a focus on structural rearrangement techniques. We highlight how these techniques can be used to generate diverse genotypes, and to accelerate the evolution of phenotypic traits. We also discuss the perspectives of directed genome evolution.
定向基因组进化在实验室中模拟基因组水平的自然进化过程，以产生所需的表型。在这里，我们回顾了最近在基因组编写和编辑方面的技术进步在定向基因组进化中的应用，重点介绍了结构重排技术。我们强调了这些技术如何用于产生多样化的基因型，并加速表型特征的进化。我们还讨论了定向基因组进化的前景。
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