Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Org Lett. 2021 Nov 5;23(21):8224-8228. doi: 10.1021/acs.orglett.1c02954. Epub 2021 Oct 15.
The Australian plant pasture-derived sp. CMB-PB042 yielded the unprecedented polycyclic -aminoglycoside-pyranonaphthoquinone polyketides glenthamine A () and glenthimine A (), the latter being a rare example of a naturally occurring imine, along with the spiropolyketide glenthol A (), its hydrolysis artifact glenthol B (), and the highly rearranged -aminoglycoside-pyranonaphthoquinone glenthamide A (). Structures including absolute configurations of - were assigned by spectroscopic analysis, chemical interconversion, and biosynthetic considerations.
澳大利亚植物 pasture-derived sp. CMB-PB042 产生了前所未有的多环 -氨基糖甙-吡喃萘醌多酮甘氨胺 A () 和甘氨胺 A (), 后者是天然存在的亚胺的罕见例子, 以及螺环多酮甘醇 A (), 其水解产物甘醇 B (), 和高度重排的 -氨基糖甙-吡喃萘醌甘氨酰胺 A (). 通过光谱分析、化学转化和生物合成考虑，确定了包括 - 的绝对构型的结构。
