Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Org Lett. 2022 Oct 14;24(40):7328-7333. doi: 10.1021/acs.orglett.2c02791. Epub 2022 Oct 6.
Molecular network analysis of sp. CMB-MW079 detected rare phosphorylated natural products. Miniaturized cultivation profiling (MATRIX) established optimal conditions for the production, isolation, and identification of the polyketide δ-lactone phoslactomycin E () and new ester homologues, phoslactomycins J and K ( and ), as well as unprecedented heterocyclic analogues, the tetrahydrofuran cyclolactomycins A-D (-) and γ-lactone isocyclolactomycins A-C (-). We propose a biogenetic relationship linking these cometabolites with the known lactomycins A-C which were tentatively identified as minor cometabolites.
对 sp. CMB-MW079 的分子网络分析检测到了罕见的磷酸化天然产物。微型化培养分析 (MATRIX) 确定了聚酮 δ-内酯磷丝菌素 E () 和新酯同系物磷丝菌素 J 和 K () 以及前所未有的杂环类似物四氢呋喃环磷丝菌素 A-D (-) 和 γ-内酯异环磷丝菌素 A-C (-) 的最佳生产、分离和鉴定条件。我们提出了一种生物发生关系，将这些共代谢物与已知的乳霉素 A-C 联系起来，乳霉素 A-C 被暂时鉴定为次要共代谢物。
