Neuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato, CA, Italy.
Present address: Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Nat Prod Res. 2022 Sep;36(17):4502-4505. doi: 10.1080/14786419.2021.1986816. Epub 2021 Oct 15.
Recent studies demonstrated that saikosaponin (SS) A and other SSs extracted from L (Apiaceae) roots abolished different behaviours motivated by drugs of abuse and palatable foods in rats. The present study was designed to investigate the effect of an SS-enriched extract fraction of roots on operant, oral self-administration of alcohol and chocolate in rats. To this end, female Sardinian alcohol-preferring and Wistar rats were trained to lever-respond for alcohol (15% v/v) and chocolate (5% w/v powdered Nesquik in water), respectively. Acute treatment with extract (0, 0.75, 1.5, and 3 mg/kg, i.p.) reduced, in a dose-related manner, both alcohol and chocolate self-administration. These data confirm the notion that extracts may be a valuable source of pharmacological agents with -addictive and anorectic potential. The use of experimental procedures with predictive validity for the human disease adds strength to the translational potential of these results.
最近的研究表明，柴胡皂苷（SS）A 和其他从 （伞形科）根中提取的 SS 消除了大鼠中不同的成瘾药物和美味食物所引起的行为。本研究旨在研究 SS 富集的 根提取物对大鼠操作性、口服酒精和巧克力自我给药的影响。为此，雌性撒丁岛酒精偏好和 Wistar 大鼠分别接受酒精（15% v/v）和巧克力（5% w/v 粉状 Nesquik 溶于水）的杠杆反应训练。 提取物（0、0.75、1.5 和 3mg/kg，ip）急性处理以剂量相关的方式减少了酒精和巧克力的自我给药。这些数据证实了 提取物可能是具有 -成瘾和厌食潜力的有价值的药理制剂来源的观点。使用对人类疾病具有预测性有效性的实验程序为这些结果的转化潜力增加了力量。
