Neuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato, Cagliari, Italy.
College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Nat Prod Res. 2023 Nov-Dec;37(24):4256-4260. doi: 10.1080/14786419.2023.2177848. Epub 2023 Feb 14.
Saikosaponin A (SSA) is an active ingredient of the Asian medicinal herb, L. When administered the intraperitoneal (i.p.) route, SSA suppressed multiple addictive-like behaviours, including operant alcohol self-administration, in rodents. It is unknown whether these effects are retained after intragastric (i.g.) administration, a desirable prerequisite for a compound with therapeutic potential. To fill this gap, i.g. SSA (0, 50, and 100 mg/kg) was tested in Sardinian alcohol-preferring (sP) rats trained to lever-respond for oral alcohol. SSA reduced lever-responding and amount of self-administered alcohol. However, when compared to i.p. SSA, i.g. SSA resulted to be markedly less potent and effective, suggestive of reduced bioavailability after i.g. treatment. Finally, and in agreement with previous data on the suppressing effect of i.p. SSA on behaviours motivated by highly palatable foods, i.g. SSA (0, 50, and 100 mg/kg) reduced oral sucrose self-administration in a separate set of sP rats.
柴胡皂苷 A（SSA）是亚洲药用植物 L. 的一种活性成分。当通过腹腔内（i.p.）途径给药时，SSA 抑制了多种类似成瘾的行为，包括操作型酒精自我给药，在啮齿动物中。目前尚不清楚这些作用在经胃内（i.g.）给药后是否保留，这是具有治疗潜力的化合物的理想前提。为了填补这一空白，经口给予 SSA（0、50 和 100mg/kg），测试其对经训练用于口服酒精的萨丁岛酒精偏好（sP）大鼠的作用。SSA 减少了杠杆反应和自我给药的酒精量。然而，与 i.p. SSA 相比，i.g. SSA 的效力和效果明显降低，提示 i.g. 治疗后生物利用度降低。最后，与 i.p. SSA 对高适口性食物驱动行为的抑制作用的先前数据一致，i.g. SSA（0、50 和 100mg/kg）减少了另一组 sP 大鼠的口服蔗糖自我给药。
