CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China.
Chem Soc Rev. 2021 Nov 15;50(22):12808-12827. doi: 10.1039/d1cs00210d.
Transition metal-catalysed asymmetric coupling has been established as a robust tool for constructing complex organic molecules. Although this area has been extensively studied, the development of efficient protocols to construct stereogenic centres with excellent regio- and enantioselectivities is highly desirable and remains challenging. Asymmetric transition metal catalysis with light intervention provides a practical alternative strategy to current methods and considerably expands the synthetic utility as a result of abundant feedstocks and mild conditions. This tutorial review comprehensively summarizes the recent advances in transition-metal-catalysed asymmetric coupling reactions with light intervention; in particular, a concise analysis of substrate scope and the mechanistic scenarios governing stereocontrol is discussed.
过渡金属催化的不对称偶联已被确立为构建复杂有机分子的强有力工具。尽管该领域已经得到了广泛的研究，但开发高效的协议来构建具有优异区域和对映选择性的立体中心仍然是非常需要的，并且仍然具有挑战性。带有光干预的不对称过渡金属催化提供了一种替代当前方法的实用策略，并且由于丰富的原料和温和的条件，大大扩展了合成的实用性。本综述全面总结了近年来在光干预下过渡金属催化的不对称偶联反应的最新进展；特别讨论了对映控制的底物范围和机械情景的简明分析。
