Hu Jiefeng, Ferger Matthias, Shi Zhuangzhi, Marder Todd B
Institute of Inorganic Chemistry, and Institute for Sustainable Chemistry & Catalysis with Boron, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, 211816 Nanjing, China.
Chem Soc Rev. 2021 Nov 29;50(23):13129-13188. doi: 10.1039/d0cs00843e.
Chiral organoboronates have played a critical role in organic chemistry and in the development of materials science and pharmaceuticals. Much effort has been devoted to exploring synthetic methodologies for the preparation of these compounds during the past few decades. Among the known methods, asymmetric catalysis has emerged as a practical and highly efficient strategy for their straightforward preparation, and recent years have witnessed remarkable advances in this respect. Approaches such as asymmetric borylative addition, asymmetric allylic borylation and stereospecific cross-coupling borylation, have been extensively explored and well established employing transition-metal catalysis with a chiral ligand. This review provides a comprehensive overview of transition metal-catalysed asymmetric borylation processes to construct carbon-boron, carbon-carbon, and other carbon-heteroatom bonds. It summarises a range of recent achievements in this area of research, with considerable attention devoted to the reaction modes and the mechanisms involved.
手性有机硼酸酯在有机化学、材料科学和药物开发中发挥了关键作用。在过去几十年里，人们投入了大量精力探索这些化合物的合成方法。在已知方法中，不对称催化已成为直接制备它们的实用且高效的策略，近年来在这方面取得了显著进展。诸如不对称硼氢化加成、不对称烯丙基硼化和立体选择性交叉偶联硼化等方法，已通过使用手性配体的过渡金属催化得到广泛探索并得以确立。本综述全面概述了过渡金属催化的不对称硼化过程，以构建碳 - 硼键、碳 - 碳键和其他碳 - 杂原子键。它总结了该研究领域的一系列最新成果，并对反应模式和相关机制给予了相当关注。
