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[一名患有慢性肉芽肿病儿童的粘质沙雷氏菌多灶性骨髓炎]

[Serratia marcescens multifocal osteomyelitis in a child with chronic granulomatous disease].

作者信息

Castro-Moraga María Eugenia, Coria Paulina, Conca Natalia, Berho Javiera, King Alejandra

机构信息

Facultad de Medicina, Universidad de Chile, Santiago, Chile.

出版信息

Rev Chilena Infectol. 2021 Aug;38(4):574-579. doi: 10.4067/S0716-10182021000400574.

Abstract

Chronic granulomatous disease (CGD) is a rare primary immuno-deficiency. It is characterized by an alteration in the function of phagocytes causing recurrent bacterial and fungal infections. This is a case report of a child with multifocal osteomyelitis by Serratia marcescens, an infrequent as a cause of bone infections, although associated with CGD. The study of infections with clinical presentation and unusual agents should lead to suspicion of CGD. The diagnosis early in life, as well as timely antimicrobial treatment and the subsequent antimicrobial prophylaxis will avoid infectious recurrences and sequelae.

摘要

慢性肉芽肿病(CGD)是一种罕见的原发性免疫缺陷病。其特征是吞噬细胞功能改变,导致反复发生细菌和真菌感染。本文报告一例由粘质沙雷氏菌引起的多灶性骨髓炎患儿,该菌作为骨感染的病因并不常见,但与CGD相关。对具有临床表现和不常见病原体的感染进行研究应引起对CGD的怀疑。早期诊断、及时的抗菌治疗以及随后的抗菌预防将避免感染复发和后遗症。

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