Pauls D L, Towbin K E, Leckman J F, Zahner G E, Cohen D J
Arch Gen Psychiatry. 1986 Dec;43(12):1180-2. doi: 10.1001/archpsyc.1986.01800120066013.
Previous studies have suggested that obsessive-compulsive symptoms frequently occur among patients with Gilles de la Tourette's syndrome (TS). To examine the relationship between TS and obsessive-compulsive disorder (OCD), data from all first-degree relatives of TS probands were obtained with a semistructured interview designed to collect information on the presence of TS, other tic disorders, and neuropsychiatric illnesses during the lifetime of the individual. The rate of OCD among first-degree relatives was significantly increased over estimates from the general population and a control sample of adoptive relatives. The rates of TS, OCD, and chronic multiple tics (CMT) were virtually the same in families of probands with OCD (TS +/- OCD) when compared with families of probands without OCD (TS - OCD). Finally, the frequency of OCD without TS or CMT among first-degree relatives was significantly elevated in families of both TS + OCD and TS - OCD probands, suggesting that some forms of OCD may represent an alternative expression of the factors responsible for TS and/or CMT.
先前的研究表明，抽动秽语综合征（TS）患者中经常出现强迫症状。为了研究TS与强迫症（OCD）之间的关系，通过半结构化访谈获取了TS先证者所有一级亲属的数据，该访谈旨在收集个体一生中TS、其他抽动障碍和神经精神疾病的相关信息。一级亲属中OCD的发生率显著高于普通人群和领养亲属的对照样本。与无OCD的先证者（TS - OCD）家庭相比，有OCD的先证者（TS +/- OCD）家庭中TS、OCD和慢性多发性抽动（CMT）的发生率几乎相同。最后，在TS + OCD和TS - OCD先证者的家庭中，一级亲属中无TS或CMT的OCD发生率均显著升高，这表明某些形式的OCD可能是导致TS和/或CMT的因素的另一种表现形式。
