Eggers Christian, Schepker Renate, Oades Robert
RLHK Klinik für Kinder- und Jugendpsychiatrie, Hufelandstrasse 55, D-4300, Essen, Germany.
Eur Child Adolesc Psychiatry. 1993 Jul;2(3):169-176. doi: 10.1007/BF02125572.
This paper deals with the problem of overlapping clinical effects of neurotropic agents in treating children with complex comorbidity. An 8-year-old boy suffering from a complexity of symptoms such as chronic motor tics, compulsions, phobias, anxious inhibition, and stuttering displayed the totality of Tourette's syndrome while taking imipramine. Sulpiride also enhanced motor and vocal tics. In the discussion, a review on the neurometabolic mechanisms in tic disease actually known is given, and on drugs proven to precipitate tics, which is the case in a number of neurotropic agents. Psychodynamics and famility dynamics are another issue to be regarded independently.
本文探讨了神经营养药物在治疗患有复杂合并症儿童时临床效果重叠的问题。一名8岁男孩患有慢性运动性抽动、强迫行为、恐惧症、焦虑抑制和口吃等多种症状，在服用丙咪嗪时表现出了妥瑞氏综合征的全部症状。舒必利也加重了运动性和发声性抽动。在讨论中，对抽动疾病中实际已知的神经代谢机制以及已证实可引发抽动的药物进行了综述，许多神经营养药物都存在这种情况。心理动力学和家庭动力学是另一个需要单独考虑的问题。
