Lai Shih-Wei, Lin Cheng-Li, Liao Kuan-Fu
College of Medicine, China Medical University, Taichung, Taiwan.
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Eur Geriatr Med. 2018 Jun;9(3):377-381. doi: 10.1007/s41999-018-0055-1. Epub 2018 Apr 9.
Little evidence is available about the association between allopurinol use and Parkinson's disease. The present study aimed to explore the association between allopurinol use and Parkinson's disease in older adults in Taiwan.
We conducted a population-based case-control study using the database of the Taiwan National Health Insurance Program. In total, 4399 subjects aged ≥ 65 years with newly diagnosed Parkinson's disease between 2000 and 2013 were included as the cases. Additionally, 4399 subjects aged ≥ 65 years without Parkinson's disease were randomly selected as the controls. Both cases and controls were matched for age and comorbidities. Ever use of allopurinol was defined as subjects who had at least a prescription for allopurinol before the index date, whereas never use of allopurinol was defined as those who never had a prescription for allopurinol before the index date. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) for the association between allopurinol use and Parkinson's disease.
The OR of Parkinson's disease was 0.93 for subjects with ever use of allopurinol (95% CI 0.82, 1.04), compared with never use.
No association can be detected between allopurinol use and Parkinson's disease in older adults in Taiwan.
关于使用别嘌醇与帕金森病之间的关联，现有证据较少。本研究旨在探讨台湾老年人中使用别嘌醇与帕金森病之间的关联。
我们利用台湾国民健康保险计划数据库进行了一项基于人群的病例对照研究。总共纳入了2000年至2013年间新诊断为帕金森病的4399名年龄≥65岁的受试者作为病例组。此外，随机选取4399名年龄≥65岁且无帕金森病的受试者作为对照组。病例组和对照组在年龄和合并症方面进行了匹配。曾经使用别嘌醇定义为在索引日期之前至少有一次别嘌醇处方的受试者，而从未使用别嘌醇定义为在索引日期之前从未有过别嘌醇处方的受试者。我们使用逻辑回归模型计算使用别嘌醇与帕金森病之间关联的比值比（OR）和95%置信区间（CI）。
与从未使用别嘌醇的受试者相比，曾经使用别嘌醇的受试者患帕金森病的OR为0.93（95%CI 0.82，1.04）。
在台湾老年人中，未发现使用别嘌醇与帕金森病之间存在关联。
