Department of Neurology, University Hospital Center Zagreb, Referral Center for Autonomic Nervous System Disorders, Zagreb, Croatia.
Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia.
Expert Rev Neurother. 2021 Dec;21(12):1409-1417. doi: 10.1080/14737175.2021.1994856. Epub 2021 Nov 17.
Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. Autonomic dysfunction (AD) is frequently present in persons with MS (pwMS) and increases with disease duration and progression.
Cardiovascular, genitourinary, and sudomotor autonomic dysfunction in pwMS are reviewed and managing of these disorders is addressed.
AD in pwMS can manifest with a myriad of symptoms including cardiovascular, urogenital, and sweating disorders. These symptoms can significantly impact the quality of life of pwMS with poor tolerance of upright position, difficulties in sexual function, and low endurance of physical activity especially in warm environments. Health professionals involved in care of pwMS should possess basic knowledge of the function of the autonomic nervous system and be informed of the way disorders of the autonomic function may manifest in pwMS in order to provide the proper care.
多发性硬化症（MS）是一种中枢神经系统的慢性脱髓鞘免疫介导疾病。自主神经功能障碍（AD）在多发性硬化症患者（pwMS）中经常出现，并随着疾病的持续时间和进展而增加。
pwMS 的心血管、泌尿生殖和出汗自主神经功能障碍得到了回顾，并对这些疾病的治疗进行了探讨。
pwMS 中的 AD 可能表现为多种症状，包括心血管、泌尿生殖和出汗障碍。这些症状会显著影响 pwMS 的生活质量，导致其难以耐受直立位、性功能障碍以及在温暖环境中体力活动的耐力降低。参与 pwMS 护理的医疗保健专业人员应具备自主神经系统功能的基本知识，并了解自主功能障碍可能在 pwMS 中表现出来的方式，以便提供适当的护理。
