Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
BMC Neurol. 2021 Oct 15;21(1):400. doi: 10.1186/s12883-021-02431-1.
Multiple Sclerosis (MS) is a burdensome, chronic and autoimmune disease of the central nervous system. We aimed to report the incidence, prevalence, mortality, and Disability Adjusted Life Years (DALYs) of MS in Iran at a national level for different age and sex groups over a period of 28 years (1990-2017).
Data were extracted from the Global Burden of Disease study (GBD) from 1990 to 2017, published by the Institute for Health Metrics and Evaluation. The incidence of DALYs and prevalence of MS were estimated to report the burden of MS based on sex and age in Iran from 1990 to 2017.
At the national level, the Age-Standardized Incidence Rate (ASIR), Age-Standardized Prevalence Rate (ASPR), Age-Standardized DALYs Rate (ASDR) and the Age-Standardized Mortality Rate (ASMR) in Iran in 2017 were 2.4 (95% Uncertainty Interval [UI]: 2.1 to 2.7), 69.5 (62.1 to 77.8), 29.1 (23.6 to 34.7), and 0.4 (0.3 to 0.4) per 100,000 population, respectively. During the period of 1990 to 2017, all measures increased, and were higher among females. The incidence rate began upward trend at the age of 20 and attained its highest level at the age of 25.
In Iran, all of the age-standardized MS rates have been increasing during the 28 years from 1990 to 2017. Our findings can help policy makers and health planners to design and communicate their plans and to have a better resource allocation, depending on the incidence and prevalence of the growing numbers of MS patients in Iran.
多发性硬化症（MS）是一种负担沉重的、慢性的和自身免疫性中枢神经系统疾病。我们旨在报告 28 年来（1990-2017 年）伊朗不同年龄和性别组多发性硬化症的发病率、患病率、死亡率和伤残调整生命年（DALYs）。
数据来自 1990 年至 2017 年全球疾病负担研究（GBD），由健康指标与评估研究所发布。根据 1990 年至 2017 年伊朗的性别和年龄，我们估计发病率和 DALY 的患病率，以报告多发性硬化症的负担。
在国家层面上，2017 年伊朗的年龄标准化发病率（ASIR）、年龄标准化患病率（ASPR）、年龄标准化 DALYs 率（ASDR）和年龄标准化死亡率（ASMR）分别为 2.4（95%不确定区间[UI]：2.1-2.7）、69.5（62.1-77.8）、29.1（23.6-34.7）和 0.4（0.3-0.4）/100,000 人。1990 年至 2017 年期间，所有指标均呈上升趋势，女性更高。发病率在 20 岁时呈上升趋势，在 25 岁时达到最高水平。
在伊朗，1990 年至 2017 年的 28 年间，所有年龄标准化 MS 率均呈上升趋势。我们的研究结果可以帮助决策者和卫生规划者根据伊朗不断增加的多发性硬化症患者数量的发病率和患病率来制定和交流计划，并进行更好的资源分配。
