Department of Neurology, Shahid Rajaei Clinical Research and Development Unit, Alborz University of Medical Sciences, Karaj, Iran.
School of Medicine, Zhejiang University, Hangzhou, China.
Brain Behav. 2024 Sep;14(9):e70031. doi: 10.1002/brb3.70031.
Pregnancy and motherhood are very valuable but challenging for women with multiple sclerosis (MS). Given that there are limited studies in this field, this study aimed to determine the social determinants of health on attitudes toward childbearing among women with MS.
We conducted a cross-sectional study on 206 women with MS in Alborz province, Iran, from February to June 2023 using convenience sampling. The data were collected using the questionnaire, and a linear regression analysis was applied.
The mean age of the participants was 36.80 ± 6.50 years. Participants' Attitudes toward Fertility and Childbearing (PAFC) had a positive significant association with social support (B = .10, SE = .04, p = .023) and a significant negative association with the total score of depression, anxiety, and stress scale (B = -.13, SE = .06, p = .047) and depression (B = -.40, SE = .18, p = .023). However, the association between anxiety (B = -.25, SE = .20, p = .211), stress (B = -.36, SE = .18, p = .050), MS severity (B = .04, SE = .30, p = .890), and socioeconomic status scale (SES) (B = -.08, SE = .32, p = .806) was nonsignificant with PAFC.
Our results showed that factors, including social support and mental health especially depression, can affect PAFC in women with MS. Therefore, it is necessary to determine specific strategies for policymakers to help MS patients manage pregnancy and motherhood.
怀孕和做母亲对患有多发性硬化症（MS）的女性来说是非常有价值但也极具挑战性的。鉴于该领域的研究有限，本研究旨在确定健康的社会决定因素对 MS 女性生育态度的影响。
我们于 2023 年 2 月至 6 月在伊朗阿尔博兹省采用便利抽样法对 206 名 MS 女性进行了横断面研究。使用问卷收集数据，并应用线性回归分析。
参与者的平均年龄为 36.80 ± 6.50 岁。参与者的生育和育儿态度（PAFC）与社会支持呈正显著相关（B=.10，SE=.04，p=.023），与抑郁、焦虑和压力量表总分（B=-.13，SE=.06，p=.047）和抑郁（B=-.40，SE=.18，p=.023）呈负显著相关。然而，焦虑（B=-.25，SE=.20，p=.211）、压力（B=-.36，SE=.18，p=.050）、MS 严重程度（B=.04，SE=.30，p=.890）和社会经济地位量表（SES）（B=-.08，SE=.32，p=.806）与 PAFC 之间的关联无统计学意义。
我们的结果表明，包括社会支持和心理健康（特别是抑郁）在内的因素会影响 MS 女性的 PAFC。因此，有必要为政策制定者确定具体策略，以帮助 MS 患者管理怀孕和做母亲。
