Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Research Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Int J Cardiol. 2022 Sep 15;363:202-209. doi: 10.1016/j.ijcard.2022.06.060. Epub 2022 Jun 28.
Endocarditis is a potentially life-threatening infectious disease associated with significant morbidity and mortality and an escalating incidence in recent decades. In this study, as a part of the global burden of disease (GBD) 2019 study, we intend to report endocarditis burden in Iran at national and provincial levels from 1990 to 2019.
This study was conducted using GBD 2019 study data on endocarditis from 1990 to 2019. We gathered incidence, prevalence, disability-adjusted life years (DALYs), and mortality rates in Iran and its 31 provinces by sex and age groups as epidemiological indices for endocarditis burden. Further decomposition analysis was also performed to delineate the endocarditis new cases trend.
On the country scale, age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized mortality rate (ASMR), and age-standardized DALYs rate were (16.5 (95% uncertainty interval 13.7 to 19.8), 3.4 (2.9 to 4.1), 0.6 (0.5 to 0.9), and 14.4 (12.0 to 21.1) in 2019, respectively. Decomposition analysis showed that only 59.2% of the overall new cases increase (114.1%) was caused by the incidence rate change. All estimated age-standardized rates were higher in men in 1990 and 2019 with a ratio of 1.1-1.5.
The ASIR and ASPR of endocarditis increased, and the ASMR and age-standardized DALYs rate declined over the past 30 years in Iran, nearly all the provinces followed the same pattern with North Khorasan having the Highest ASIR, ASPR, ASMR, and DALYs rates in both years. High systolic blood pressure (SBP) had the greatest attributed burden among risk factors.
心内膜炎是一种潜在的危及生命的传染病，与较高的发病率和死亡率以及近几十年来不断上升的发病率有关。在这项研究中，作为 2019 年全球疾病负担 (GBD) 研究的一部分，我们旨在报告 1990 年至 2019 年伊朗全国和省级的心内膜炎负担。
本研究使用 1990 年至 2019 年 GBD 2019 研究中的心内膜炎数据进行。我们收集了伊朗及其 31 个省份按性别和年龄组划分的心内膜炎发病率、患病率、残疾调整生命年 (DALY) 和死亡率等流行病学指标。还进行了进一步的分解分析，以描绘心内膜炎新发病例的趋势。
从全国范围来看，年龄标准化发病率 (ASIR)、年龄标准化患病率 (ASPR)、年龄标准化死亡率 (ASMR) 和年龄标准化 DALY 率分别为 (16.5 (95%置信区间 13.7 至 19.8)、3.4 (2.9 至 4.1)、0.6 (0.5 至 0.9) 和 14.4 (12.0 至 21.1)。分解分析表明，只有 59.2%的总体新发病例增加 (114.1%)是由发病率变化引起的。1990 年和 2019 年，所有估计的年龄标准化率在男性中均较高，比率为 1.1-1.5。
在过去的 30 年里，伊朗的心内膜炎 ASIR 和 ASPR 增加，ASMR 和年龄标准化 DALY 率下降，几乎所有省份都遵循相同的模式，北霍拉桑在这两年的 ASIR、ASPR、ASMR 和 DALY 率均为最高。高血压 (SBP) 是危险因素中导致负担最重的因素。
