Gaba S, Trigui F, Dujols P, Godard P, Michel F B, Prefaut C
Eur J Respir Dis Suppl. 1986;146:515-22.
Pulmonary human vasomotor effects of purine nucleotides are unknown. We compared hemodynamic and gasometric effects of ATP vs ADO, using equimolar infusion rate, on 18 chronically hypoxemic COPD patients. ATP infusion (1 and 2 micro Mole per kilo over 20 min) induced pulmonary vasodilation, with a significant decrease of Ppa (-14% -p = 0.025), PVR (-26.6% p = 0.05) and PaO2 (-10.9% p = 0.025). No change was observed when ADO and control solvent were infused. The pulmonary vasodilator effect of infused ATP on COPD patients, seems to be independent of circulating ADO.
嘌呤核苷酸对人体肺部血管运动的影响尚不清楚。我们以等摩尔输注速率，比较了ATP与ADO对18例慢性低氧性慢性阻塞性肺疾病（COPD）患者的血流动力学和气体测量效应。输注ATP（20分钟内每公斤1和2微摩尔）可引起肺血管舒张，平均肺动脉压（Ppa）显著降低（-14%，p = 0.025），肺血管阻力（PVR）降低（-26.6%，p = 0.05），动脉血氧分压（PaO2）降低（-10.9%，p = 0.025）。输注ADO和对照溶剂时未观察到变化。输注的ATP对COPD患者的肺血管舒张作用似乎与循环中的ADO无关。
