谷胱甘肽在逆转硫醇氧化剂对大肠杆菌的有害作用中的作用。
Role of glutathione in reversing the deleterious effects of a thiol-oxidizing agent in Escherichia coli.
作者信息
Hibberd K A, Berget P B, Warner H R, Fuchs J A
出版信息
J Bacteriol. 1978 Mar;133(3):1150-5. doi: 10.1128/jb.133.3.1150-1155.1978.
Abstract
Diamide was found to be much less specific for the oxidation of glutathione in vivo in Escherichia coli than had been previously assumed. In vivo, only a slight alteration of the ratio of reduced to oxidized glutathione was found, whereas a significant amount of glutathione was found in the form of mixed disulfide with proteins. This latter occurrence was postulated as being responsible for the bacteriostatic effect of diamide.
摘要
人们发现，二酰胺对大肠杆菌体内谷胱甘肽氧化作用的特异性远低于先前的假设。在体内，仅发现还原型谷胱甘肽与氧化型谷胱甘肽的比例有轻微变化，而大量谷胱甘肽以与蛋白质形成混合二硫键的形式存在。后一种情况被认为是二酰胺产生抑菌作用的原因。
相似文献
1
Role of glutathione in reversing the deleterious effects of a thiol-oxidizing agent in Escherichia coli.谷胱甘肽在逆转硫醇氧化剂对大肠杆菌的有害作用中的作用。
J Bacteriol. 1978 Mar;133(3):1150-5. doi: 10.1128/jb.133.3.1150-1155.1978.
2
Diamide induced shift in protein and glutathione thiol: disulfide status delays DNA rejoining after X-irradiation of human cancer cells.二酰胺诱导的蛋白质和谷胱甘肽硫醇：二硫键状态的改变会延迟人类癌细胞经X射线照射后的DNA重新连接。
Biochim Biophys Acta. 1990 Jan 19;1037(1):39-47. doi: 10.1016/0167-4838(90)90099-2.
3
Regulation of rat liver microsomal glutathione S-transferase activity by thiol/disulfide exchange.通过硫醇/二硫键交换对大鼠肝脏微粒体谷胱甘肽S-转移酶活性的调节
Arch Biochem Biophys. 1989 Apr;270(1):330-4. doi: 10.1016/0003-9861(89)90035-0.
4
Effect of the thiol-oxidizing agent diamide on the growth of Escherichia coli.硫醇氧化剂二酰胺对大肠杆菌生长的影响。
J Bacteriol. 1970 Mar;101(3):1092-3. doi: 10.1128/jb.101.3.1092-1093.1970.
5
[Formation of mixed disulfides of glutathione and protein under the action of diamide].
Dokl Akad Nauk SSSR. 1978;240(2):467-70.
6
Diamide acts intracellularly to enhance transmitter release: the differential permeation of diamide, DIP, DIP+1 and DIP+2 across the nerve terminal membrane.二酰胺在细胞内起作用以增强递质释放：二酰胺、DIP、DIP + 1和DIP + 2穿过神经末梢膜的差异渗透。
Brain Res. 1976 Nov 26;117(2):277-85. doi: 10.1016/0006-8993(76)90735-6.
7
Protein mixed-disulfides in cardiac cells. S-thiolation of soluble proteins in response to diamide.
Biochim Biophys Acta. 1985 Jan 18;844(1):50-4. doi: 10.1016/0167-4889(85)90232-0.
8
The role of functional sulfhydryl groups in active transport in Escherichia coli membrane vesicles.
Biochemistry. 1978 May 2;17(9):1640-6. doi: 10.1021/bi00602a010.
9
Thiol-dependent K:Cl transport in sheep red cells: VIII. Activation through metabolically and chemically reversible oxidation by diamide.绵羊红细胞中硫醇依赖性钾氯转运：VIII. 通过二酰胺进行代谢和化学可逆氧化激活。
J Membr Biol. 1988;101(2):179-88. doi: 10.1007/BF01872833.
10
A comparison of protein S-thiolation (protein mixed-disulfide formation) in heart cells treated with t-butyl hydroperoxide or diamide.用叔丁基过氧化氢或二酰胺处理的心脏细胞中蛋白质S-硫醇化（蛋白质混合二硫键形成）的比较。
Biochim Biophys Acta. 1986 Jan 23;885(1):58-67. doi: 10.1016/0167-4889(86)90038-8.
引用本文的文献
1
Redox interconversion of Escherichia coli glutathione reductase. A study with permeabilized and intact cells.大肠杆菌谷胱甘肽还原酶的氧化还原互变。对透化细胞和完整细胞的研究。
Mol Cell Biochem. 1985 Oct;68(2):121-30. doi: 10.1007/BF00219376.
2
Glutathione reductase is not required for maintenance of reduced glutathione in Escherichia coli K-12.在大肠杆菌K-12中，维持还原型谷胱甘肽并不需要谷胱甘肽还原酶。
J Bacteriol. 1985 Apr;162(1):448-50. doi: 10.1128/jb.162.1.448-450.1985.
本文引用的文献
1
Mutants of Escherichia coli requiring methionine or vitamin B12.需要甲硫氨酸或维生素B12的大肠杆菌突变体。
J Bacteriol. 1950 Jul;60(1):17-28. doi: 10.1128/jb.60.1.17-28.1950.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
4
Diamide, a new reagent for the intracellular oxidation of glutathione to the disulfide.二酰胺，一种将细胞内谷胱甘肽氧化为二硫键的新型试剂。
Biochem Biophys Res Commun. 1969 Nov 6;37(4):593-6. doi: 10.1016/0006-291x(69)90850-x.
5
Effect of the thiol-oxidizing agent diamide on the growth of Escherichia coli.硫醇氧化剂二酰胺对大肠杆菌生长的影响。
J Bacteriol. 1970 Mar;101(3):1092-3. doi: 10.1128/jb.101.3.1092-1093.1970.
6
Isolation of an Escherichia coli mutant deficient in glutathione synthesis.一株谷胱甘肽合成缺陷型大肠杆菌突变体的分离。
J Bacteriol. 1975 Oct;124(1):140-8. doi: 10.1128/jb.124.1.140-148.1975.
7
Isolation and initial characterization of glutathione-deficient mutants of Escherichia coli K 12.大肠杆菌K12谷胱甘肽缺陷型突变体的分离与初步鉴定
Biochim Biophys Acta. 1975 Jul 14;399(1):10-22. doi: 10.1016/0304-4165(75)90206-8.
Zotero 插件