三级医疗城市中的抗菌药物相关性过敏反应
Antimicrobial-associated anaphylaxis at a tertiary care medical city.
作者信息
Abu Esba Laila Carolina, Al Sehli Faisal Aqeel
机构信息
Pharmaceutical Care Services, King Abdulaziz Medical City - Ministry of National Guard, Health Affairs, Saudi Arabia; College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia; King Abdullah International Medical Research Centre, Saudi Arabia.
出版信息
Int Immunopharmacol. 2021 Dec;101(Pt B):108228. doi: 10.1016/j.intimp.2021.108228. Epub 2021 Oct 14.
BACKGROUND
Antimicrobial-associated anaphylaxis occurs at different rates and can lead to worsening infection-related outcomes, we sought to describe the incidence and complications of such episodes at a tertiary care hospital.
METHOD
A retrospective cohort study was conducted between January 2016 and December 2019. Cases of antimicrobial-associated anaphylaxis were identifiedusing the hospital's electronic healthcare records. Outcomes included: mortality related to anaphylaxis, infection-related mortality, hospitalization and impact on antimicrobial prescribing.
RESULTS
The estimated rate of antimicrobial-associated anaphylaxis was 18.6 (95% CI: 11.8-29.5) cases per 100,000 exposures, which required hospitalization in 23.8% of the cases and ICU admission in 19% of the cases.
CONCLUSION
Implications from antimicrobial-associated anaphylaxis is beyond the episode itself, and can be associated with poor clinical outcomes such as infection-related mortality and hospitalization.
背景
抗菌药物相关性过敏反应发生率各异，且可能导致感染相关结局恶化，我们试图描述一家三级医院此类事件的发生率及并发症情况。
方法
于2016年1月至2019年12月进行一项回顾性队列研究。利用医院电子医疗记录识别抗菌药物相关性过敏反应病例。结局包括：过敏反应相关死亡率、感染相关死亡率、住院情况以及对抗菌药物处方的影响。
结果
抗菌药物相关性过敏反应的估计发生率为每10万次暴露18.6例（95%置信区间：11.8 - 29.5），其中23.8%的病例需要住院治疗，19%的病例需要入住重症监护病房。
结论
抗菌药物相关性过敏反应的影响不仅限于事件本身，还可能与感染相关死亡率和住院等不良临床结局有关。
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