Pittaway D E, Fayez J A
Fertil Steril. 1986 Nov;46(5):790-5. doi: 10.1016/s0015-0282(16)49812-2.
CA-125, a cell-surface antigen, was measured by a radioimmunoassay in the serum of 414 women to determine its potential usefulness in the diagnosis and management of endometriosis. In women with minimal, mild, moderate, and severe endometriosis, the mean levels (+/- standard deviation) were 13.6 +/- 6.8, 22.8 +/- 15.5, 27 +/- 17, and 50 +/- 28 U/ml, respectively, and were significantly higher than mean levels (7.8 +/- 4.1) in 46 women with a normal laparoscopic examination. Higher mean CA-125 values also were observed in acute pelvic inflammatory disease, unexplained fertility, and pregnancy and during menstruation. The mean CA-125 value in women with treated endometriosis and a negative second-look laparoscopy was significantly lower than in women with untreated endometriosis. With the use of the 95% upper limit of 16 U/ml, the test had a sensitivity of 53% and specificity of 93%. The frequencies of elevated levels in minimal, mild, moderate, and severe endometriosis were 27%, 68%, 73%, and 100%, respectively. Changes in the CA-125 levels correlated with the clinical course of endometriosis in 37 of 44 (84%) women (P less than 0.001). The determination of CA-125 levels may assist in the evaluation and treatment of women with endometriosis.
CA - 125是一种细胞表面抗原，通过放射免疫分析法对414名女性的血清进行检测，以确定其在子宫内膜异位症诊断和管理中的潜在用途。患有轻微、轻度、中度和重度子宫内膜异位症的女性，其平均水平（±标准差）分别为13.6±6.8、22.8±15.5、27±17和50±28 U/ml，显著高于46名腹腔镜检查正常女性的平均水平（7.8±4.1）。在急性盆腔炎、不明原因的不孕症、妊娠及月经期间也观察到较高的CA - 125平均水平。接受过治疗且二次腹腔镜检查结果为阴性的子宫内膜异位症女性的CA - 125平均水平显著低于未接受治疗的女性。以16 U/ml的95%上限值为标准，该检测的灵敏度为53%，特异性为93%。轻微、轻度、中度和重度子宫内膜异位症中CA - 125水平升高的频率分别为27%、68%、73%和100%。44名女性中有37名（84%）的CA - 125水平变化与子宫内膜异位症的临床病程相关（P<0.001）。CA - 125水平的测定可能有助于对子宫内膜异位症女性进行评估和治疗。
