Marchi Saverio, Morroni Gianluca, Pinton Paolo, Galluzzi Lorenzo
Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
Department of Biomedical Sciences & Public Health, Marche Polytechnic University, Ancona, Italy.
Trends Microbiol. 2022 May;30(5):452-465. doi: 10.1016/j.tim.2021.09.010. Epub 2021 Oct 13.
Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. Here, we discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.
线粒体控制着对细胞和机体稳态至关重要的各种过程，包括钙通量、生物能量代谢和细胞死亡。或许不足为奇的是，多种致病细菌已经进化出策略来破坏线粒体功能，以支持它们的生存和传播。在这里，我们讨论非免疫性致病机制，这些机制都集中在细菌控制宿主细胞线粒体区室的能力上。
