大肠杆菌的吡哆醇需求型突变体：乙醇醛脱氢酶不是由pdxB基因编码的。
Pyridoxine-requiring mutants of Escherichia coli: glycolaldehyde dehydrogenase is not coded for by the pdxB gene.
作者信息
Shimizu S, Dempsey W B
出版信息
J Bacteriol. 1978 Mar;133(3):1273-7. doi: 10.1128/jb.133.3.1273-1277.1978.
Abstract
Twenty-seven independent pyridoxineless mutants belonging to genetic linkage group I were assayed for glycolaldehyde dehydrogenase. Some mutants lacked enzyme activity entirely, and others showed activity ranging from very low to wild-type levels. Reversion to pyridoxine independence usually had no effect upon this activity. Transfer of the pyridoxine genes to a common host that had wild-type levels of enzyme activity made the recipient pyridoxineless without affecting the activity. These results negate the idea of an obligatory role for glycolaldehyde dehydrogenase in pyridoxine biosynthesis.
摘要
对属于遗传连锁群I的27个独立的无维生素B6突变体进行了乙醇醛脱氢酶检测。一些突变体完全缺乏酶活性，而另一些突变体的活性则从极低到野生型水平不等。回复到不依赖维生素B6的状态通常对这种活性没有影响。将维生素B6基因转移到具有野生型酶活性水平的共同宿主中，使受体成为无维生素B6的状态，而不影响活性。这些结果否定了乙醇醛脱氢酶在维生素B6生物合成中起必不可少作用的观点。
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Characterization of pyridoxine auxotrophs of Escherichia coli: chromosomal position of linkage group I.大肠杆菌吡哆醇营养缺陷型的特性：连锁群I的染色体位置
J Bacteriol. 1969 Oct;100(1):295-300. doi: 10.1128/jb.100.1.295-300.1969.
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Characterization of pyridoxine auxotrophs of Escherichia coli: P1 transduction.大肠杆菌维生素B6营养缺陷型的特性：P1转导
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J Bacteriol. 1972 Nov;112(2):726-35. doi: 10.1128/jb.112.2.726-735.1972.
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