大肠杆菌中维生素B6生物合成的调控
Control of vitamin B 6 biosynthesis in Escherichia coli.
作者信息
Dempsey W B
出版信息
J Bacteriol. 1971 Oct;108(1):415-21. doi: 10.1128/jb.108.1.415-421.1971.
Abstract
Pyridoxineless mutants of Escherichia coli B which specifically require pyridoxal or pyridoxamine for growth can be divided into classes according to their growth responses in enriched media. Members of the slowest growing class synthesize vitamin B(6) at the fastest rates when starved for pyridoxal in glycerol minimal medium. After 80 min of synthesis at 4 x 10(-10) moles of vitamin B(6) per mg of cells per hr, the rate increases four- to fivefold and continues at the new rate for several hours. The shift to the new rate is prevented by chloramphenicol, thus suggesting that a derepression mechanism exists to control vitamin B(6) synthesis in addition to the previously discovered feedback control.
摘要
特别需要吡哆醛或吡哆胺才能生长的大肠杆菌B无吡哆醇突变体，可根据它们在富集培养基中的生长反应分为不同类别。生长最慢的类别中的成员，在甘油基本培养基中缺乏吡哆醛饥饿时，以最快的速度合成维生素B6。在每毫克细胞每小时合成4×10⁻¹⁰摩尔维生素B6的80分钟后，合成速率增加四到五倍，并以新的速率持续数小时。氯霉素可阻止向新速率的转变，因此表明除了先前发现的反馈控制外，还存在一种去阻遏机制来控制维生素B6的合成。
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