Villars T A, Burdick M
Gen Comp Endocrinol. 1986 Aug;63(2):157-61. doi: 10.1016/0016-6480(86)90151-6.
Prostaglandins (PGs) can affect sexual behavior in a range of vertebrates including goldfish, paradise fish, lizards, frogs, hamsters, and rats. Behavioral responsiveness to PG treatment has not previously been reported to correlate with reproductive condition. Earlier work (Villars et al., 1985) has suggested that in paradise fish, response to PG treatment may be limited to the period immediately following spawning. In the present experiment, prespawned females were tested for their response to intraperitoneal injection of PGF2 alpha (300 ng/g body wt) at 1 (n = 10), 3 (n = 8), or 5 (n = 8) days postspawning. Only pairs tested 1 day postspawning responded to PG-treatment of the female with spawning acts (curving or inverting). Moreover, 1 day PG-treated females showed significantly increased sexual motivation, as measured by the time the female spent under the nest with a nest-building male and by the frequency of female sexual solicitation, while the 3-day and the 5-day postspawning females showed no discernible response to PG treatment. Though differential behavioral experience had been suspected to account for female unresponsiveness seen in earlier work, it now seems possible that physiological changes post spawning may render the females unresponsive to PG treatment.
前列腺素（PGs）可影响一系列脊椎动物的性行为，包括金鱼、斗鱼、蜥蜴、青蛙、仓鼠和大鼠。此前尚未报道过对PG治疗的行为反应与生殖状况相关。早期的研究（Villars等人，1985年）表明，在斗鱼中，对PG治疗的反应可能仅限于产卵后的 immediately 期。在本实验中，对产卵前的雌性在产卵后1天（n = 10）、3天（n = 8）或5天（n = 8）进行腹腔注射PGF2α（300 ng/g体重）后的反应进行了测试。只有在产卵后1天测试的配对中，雌性接受PG治疗后会出现产卵行为（弯曲或翻转）。此外，通过雌性与筑巢雄性在巢下停留的时间以及雌性性引诱的频率来衡量，1天接受PG治疗的雌性表现出明显增加的性动机，而产卵后3天和5天的雌性对PG治疗没有明显反应。尽管在早期研究中曾怀疑不同的行为经历是导致雌性无反应的原因，但现在看来，产卵后的生理变化可能使雌性对PG治疗无反应。
