Scientific Research Center Suriname, Academic Hospital Paramaribo, Paramaribo, Suriname; Department of Medical Microbiology, Academic Medical Center, Amsterdam, the Netherlands.
Department of Infectious Diseases, Public Health Service Amsterdam (GGD), Amsterdam, the Netherlands; Stichting HIV Monitoring, Amsterdam, the Netherlands.
Virology. 2021 Dec;564:53-61. doi: 10.1016/j.virol.2021.09.005. Epub 2021 Sep 25.
Epidemiological data on hepatitis B virus (HBV) are needed to benchmark HBV elimination goals. We recently assessed prevalence of HBV infection and determinants in participants attending the Emergency Department in Paramaribo, Suriname, South America. Overall, 24.5% (95%CI = 22.7-26.4%) of participants had anti-Hepatitis B core antibodies, which was associated with older age (per year, adjusted Odds Ratio [aOR] = 1.03, 95%CI = 1.02-1.04), Afro-Surinamese (aOR = 1.84, 95%CI = 1.52-2.19) and Javanese ethnicity (aOR = 1.63, 95%CI = 1.28-2.07, compared to the grand mean). 3.2% of participants were Hepatitis B surface Ag-positive, which was also associated with older age (per year, aOR = 1.02, 95%CI = 1.00-1.04), Javanese (aOR = 4.3, 95%CI = 2.66-6.95) and Afro-Surinamese ethnicity (aOR = 2.36, 95%CI = 1.51-3.71). Sex, nosocomial or culturally-related HBV transmission risk-factors were not associated with infection. Phylogenetic analysis revealed strong ethnic clustering: Indonesian subgenotype HBV/B3 among Javanese and African subgenotypes HBV/A1, HBV/QS-A3 and HBV/E among Afro-Surinamese. Testing for HBV during adulthood should be considered for individuals living in Suriname, specifically with Javanese and Afro-Surinamese ancestry.
需要乙型肝炎病毒 (HBV) 的流行病学数据来衡量 HBV 消除目标。我们最近评估了参加南美洲苏里南帕拉马里博急诊部的参与者的 HBV 感染和决定因素。总体而言，24.5%（95%CI=22.7-26.4%）的参与者具有抗乙型肝炎核心抗体，这与年龄较大（每年，调整后的优势比[aOR]=1.03，95%CI=1.02-1.04）、非裔苏里南人（aOR=1.84，95%CI=1.52-2.19）和爪哇族裔（aOR=1.63，95%CI=1.28-2.07，与平均水平相比）相关。3.2%的参与者乙型肝炎表面抗原呈阳性，这也与年龄较大（每年，aOR=1.02，95%CI=1.00-1.04）、爪哇族裔（aOR=4.3，95%CI=2.66-6.95）和非裔苏里南人（aOR=2.36，95%CI=1.51-3.71）相关。性别、医院或文化相关的 HBV 传播风险因素与感染无关。系统发生分析显示出强烈的族裔聚类：爪哇人携带印度尼西亚亚基因型 HBV/B3，非裔苏里南人携带非洲亚基因型 HBV/A1、HBV/QS-A3 和 HBV/E。应考虑对生活在苏里南的个体，特别是有爪哇和非裔苏里南血统的个体进行 HBV 检测。
