Institute of Polymers, Composites and Biomaterials, National Research Council, IPCB-CNR, Viale J.F. Kennedy 54, Naples, 80125, Italy.
Altergon Italia s.r.l, Zona Industriale ASI, Morra De Sanctis (AV), 83040, Italy.
Macromol Biosci. 2022 Jan;22(1):e2100304. doi: 10.1002/mabi.202100304. Epub 2021 Nov 1.
Cancer is the main cause of fatality all over the world with a considerable growth rate. Many biologically active nanoplatforms are exploited for tumor treatment. Of nanodevices, hyaluronic acid (HA)-based systems have shown to be promising candidates for cancer therapy due to their high biocompatibility and cell internalization. Herein, surface functionalization of different nanoparticles (NPs), e.g., organic- and inorganic-based NPs, is highlighted. Subsequently, HA-based nanostructures and their applications in cancer therapy are presented.
癌症是全球死亡率的主要原因，且其增长率相当高。许多具有生物活性的纳米平台被用于肿瘤治疗。在纳米器件中，基于透明质酸（HA）的系统由于其高生物相容性和细胞内化而被证明是癌症治疗的有前途的候选物。本文重点介绍了不同纳米粒子（NPs）的表面功能化，例如有机和无机基 NPs。随后介绍了基于 HA 的纳米结构及其在癌症治疗中的应用。
