Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, China.
College of Natural Resources and Environment, South China Agricultural University, Guangzhou, China.
Crit Rev Food Sci Nutr. 2023;63(19):3634-3652. doi: 10.1080/10408398.2021.1991883. Epub 2021 Oct 16.
Abnormal glucose homeostasis is linked to a variety of metabolic syndromes, such as insulin resistance, obesity, type-2 diabetes mellitus, hypertension and cardiovascular diseases. Maintenance of normal glucose homeostasis is important for the body to keep normal biological functions. As the major bioactive ingredient in chili peppers responsible for the pungent flavor, capsaicin has been reported to effectively improve glucose homeostasis with low cytotoxicity. In this review, the modulating effects of capsaicin on glucose homeostasis in cell models, animal models and human trials are summarized through both TRPV1 dependent and TRPV1 independent pathways. The relevant molecular mechanisms underlying its regulatory effects are also evaluated. Understanding the effects and mechanisms of capsaicin on glucose metabolism could provide theoretical evidence for its application in the food and pharmaceutical industries.
葡萄糖稳态异常与多种代谢综合征相关，如胰岛素抵抗、肥胖、2 型糖尿病、高血压和心血管疾病。维持正常的葡萄糖稳态对于身体保持正常的生物学功能非常重要。辣椒素作为辣椒中的主要生物活性成分，负责产生辣味，已被报道具有低细胞毒性的有效改善葡萄糖稳态的作用。本综述通过 TRPV1 依赖和 TRPV1 非依赖途径，总结了辣椒素在细胞模型、动物模型和人体试验中对葡萄糖稳态的调节作用。还评估了其调节作用的相关分子机制。了解辣椒素对葡萄糖代谢的影响及其机制可为其在食品和制药行业的应用提供理论依据。
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