KU Leuven Department of Rehabilitation Sciences, Leuven, Belgium.
University Psychiatric Center KU Leuven, Leuven, Belgium.
J Appl Res Intellect Disabil. 2022 Mar;35(2):301-311. doi: 10.1111/jar.12949. Epub 2021 Oct 17.
This meta-analysis aims to: (i) describe the pooled prevalence of diabetes in people with intellectual disabilities, (ii) investigate the association with demographic, clinical and treatment-related factors and (iii) compare the prevalence versus age- and gender-matched general population controls.
Pubmed, Embase and CINAHL were searched until 01 May 2021. Random effects meta-analysis and an odds ratio analysis were conducted to compare rates with controls.
The trim- and fill-adjusted pooled diabetes prevalence amongst 55,548 individuals with intellectual disabilities (N studies = 33) was 8.5% (95% CI = 7.2%-10.0%). The trim- and fill-adjusted odds for diabetes was 2.46 times higher (95% CI = 1.89-3.21) (n = 42,684) versus controls (n = 4,177,550). Older age (R = .83, p < .001), smoking (R = .30, p = .009) and co-morbid depression (R = .18, p = .04), anxiety (R = .97, p < .001), and hypertension (R = 0.29, p < .001) were associated with higher diabetes prevalence rates.
Our findings demonstrate that people with intellectual disabilities are at an increased risk of diabetes, and therefore routine screening and multidisciplinary management of diabetes is needed.
本荟萃分析旨在：（i）描述智力障碍人群中糖尿病的总患病率，（ii）研究与人口统计学、临床和治疗相关因素的关联，以及（iii）比较与年龄和性别匹配的一般人群对照的患病率。
检索了 Pubmed、Embase 和 CINAHL，截至 2021 年 5 月 1 日。采用随机效应荟萃分析和优势比分析比较与对照组的比率。
在 33 项研究的 55548 名智力障碍个体（N 研究=33）中，经过修剪和填充调整后的糖尿病总患病率为 8.5%（95%CI=7.2%-10.0%）。经过修剪和填充调整后的糖尿病优势比为 2.46 倍（95%CI=1.89-3.21）（n=42684），高于对照组（n=4177550）。年龄较大（R=0.83，p<.001）、吸烟（R=0.30，p=.009）和共患抑郁（R=0.18，p=.04）、焦虑（R=0.97，p<.001）和高血压（R=0.29，p<.001）与更高的糖尿病患病率相关。
我们的研究结果表明，智力障碍人群患糖尿病的风险增加，因此需要常规筛查和多学科管理糖尿病。
