Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu 610052, China.
School of Clinical Medical College & Affiliated Hospital, Chengdu University, Chengdu 610052, China.
J Nat Prod. 2021 Nov 26;84(11):2866-2874. doi: 10.1021/acs.jnatprod.1c00585. Epub 2021 Oct 18.
Syringin (), a natural bioactive glucoside isolated from the root of (Rupr. Maxim.) Harms, possesses significant anti-inflammatory activity. In this study, we have accomplished the total syntheses of syringin (), along with its natural analogues -, from a common starting material, syringaldehyde (), in 4-8 steps with an overall yields of 11.8-61.3%. The anti-inflammatory activities of these compounds were determined against NO production in the LPS-stimulated RAW264.7 cells. Among them, compounds -, , and exhibited different levels of anti-inflammatory activity.
丁香苷（），一种从 （Rupr. Maxim.）哈姆斯根中分离得到的天然生物活性葡萄糖苷，具有显著的抗炎活性。在本研究中，我们以丁香醛（）为起始原料，通过 4-8 步反应，以 11.8-61.3%的总收率，完成了丁香苷（）及其天然类似物 - 的全合成。这些化合物的抗炎活性通过 LPS 刺激的 RAW264.7 细胞中 NO 生成的抑制活性来评价。其中，化合物 - 、- 、- 表现出不同水平的抗炎活性。
