Nuclear Facilities of Serbia, Vinča, Serbia.
Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Niš, Serbia.
Nat Prod Res. 2022 Sep;36(17):4536-4539. doi: 10.1080/14786419.2021.1990918. Epub 2021 Oct 16.
Methanol extracts of , , and from Serbia at concentrations of 1.00; 2.00 and 4.00 μg/ml, and as pure compounds identified in examined extracts (ferulic acid, rutin, rosmarinic acid, and quercetin) were examined for their effects on micronucleus distribution in human lymphocytes . All extracts greatly reduced the number of micronuclei in the concentration of 2.00 μg/ml comparing to the control, whereby extract exhibited the most prominent effect on decreasing frequency of micronucleus (45.2%), followed by extracts of , , and . The same declining trend was observed for the extracts at concentrations of 4.00 µg/ml, and 1.00 µg/ml, respectively. Among pure compounds (concentration 2.00 μg/ml), rutin showed the most pronounced effect on decreasing frequency of micronucleus (41.7%), higher than ferulic acid, quercetin, and rosmarinic acid comparing to the control.
从塞尔维亚获得的、 、 和 的甲醇提取物，浓度分别为 1.00、2.00 和 4.00μg/ml，以及在被检查的提取物中鉴定出的纯化合物（阿魏酸、芦丁、迷迭香酸和槲皮素），研究了它们对人淋巴细胞微核分布的影响。与对照组相比，所有提取物在浓度为 2.00μg/ml 时大大降低了微核数量，其中提取物对降低微核频率的作用最为显著（45.2%），其次是 、 、 和 的提取物。在浓度为 4.00μg/ml 和 1.00μg/ml 时，也观察到了相同的下降趋势。在纯化合物中（浓度 2.00μg/ml），芦丁对降低微核频率的作用最为显著（41.7%），高于阿魏酸、槲皮素和迷迭香酸与对照组相比。
