Khan Sohaib, Sharaf Mohamed, Ahmed Ishfaq, Khan Tehsin Ullah, Shabana Samah, Arif Muhammad, Kazmi Syed Shabi Ul Hassan, Liu Chenguang
Department of Biochemistry and Molecular Biology, College of Marine Life Sciences, Ocean University of China, Qingdao, China.
Department of Biochemistry, Faculty of Agriculture, AL-Azhar University, Nasr City, Egypt.
Expert Rev Anti Infect Ther. 2022 Mar;20(3):407-424. doi: 10.1080/14787210.2022.1990041. Epub 2021 Oct 17.
() has occupied a significant place among infectious pathogens and it has been documented as a leading challenge due to its higher resistance to the commonly used drugs, higher adaptability, and lower targeting specificity of the available drugs.
New treatment strategies are urgently needed in order to improve the current advancement in modern medicine. Nanocarriers have gained an advantage of drug encapsulation and high retention time in the stomach with a prolonged drug release rate at the targeted site. This article aims to highlight the recent advances in nanotechnology with special emphasis on metallic, polymeric, lipid, membrane coated, and target-specific nanoparticles (NPs), as well as, natural products for treating infection. We discussed a comprehensive approach to understand infection and elicits to rethink about the increasing threat posed by and its treatment strategies.
To address these issues, nanotechnology has got huge potential to combat infection and has made great progress in the field of biomedicine. Moreover, combinatory studies of natural products and probiotics in conjugation with NPs have proven efficiency against infection, with an advantage of lower cytotoxicity, minimal side effects, and stronger antibacterial potential.[Figure: see text].
()在传染性病原体中占据重要地位,由于其对常用药物具有更高的耐药性、更强的适应性以及现有药物较低的靶向特异性,它已被记录为一个主要挑战。
迫切需要新的治疗策略以提升现代医学的当前进展。纳米载体在药物封装方面具有优势,并且在胃中具有高保留时间,在靶向部位具有延长的药物释放速率。本文旨在突出纳米技术的最新进展,特别强调金属、聚合物、脂质、膜包被和靶向特异性纳米颗粒(NPs),以及用于治疗感染的天然产物。我们讨论了一种全面的方法来理解感染,并促使人们重新思考()所带来的日益增加的威胁及其治疗策略。
为解决这些问题,纳米技术在对抗感染方面具有巨大潜力,并且在生物医学领域取得了重大进展。此外,天然产物和益生菌与纳米颗粒结合的联合研究已证明对感染有效,具有较低细胞毒性、最小副作用和更强抗菌潜力的优势。[图:见正文]