Tahir Adnan Hassan, Li Jia-Jia, Tang Yong
School of Acupuncture and Tuina and International Collaborative Centre on Big Science Plan for Purinergic Signalling, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Acupuncture and Chronobiology Key Laboratory of Sichuan Province, Chengdu, China.
Front Neurosci. 2021 Sep 28;15:696843. doi: 10.3389/fnins.2021.696843. eCollection 2021.
One of the important characteristic features of clinically significant gastrointestinal disorders is visceral hypersensitivity (VH). Pain sensitization or VH is a big challenge for clinicians and becomes a very thorny work in clinical practices; the therapeutic efficacy for VH results in limited success. A popular second therapy that is being approved for the induction of analgesia and attenuates VH with fewer side effects includes electro-acupuncture (EA). Different peripheral and spinal neurological chemicals, including neurotransmitters, neuropeptides, and cytokines, and different signaling pathways were associated with EA treatment in VH. Despite the higher acceptance of EA, the underlying mechanism still needs to be further explored. In this paper, we review the available literature to find the peripheral and spinal mechanisms involved in EA to relieve VH.
临床上显著的胃肠道疾病的重要特征之一是内脏高敏感性（VH）。疼痛敏化或VH对临床医生来说是一个巨大挑战，并且在临床实践中成为一项非常棘手的工作；VH的治疗效果导致成功有限。一种正在被批准用于诱导镇痛且副作用较少地减轻VH的常用二线疗法包括电针（EA）。不同的外周和脊髓神经化学物质，包括神经递质、神经肽和细胞因子，以及不同的信号通路与VH中EA治疗相关。尽管EA的接受度较高，但其潜在机制仍需进一步探索。在本文中，我们回顾现有文献以找出EA缓解VH所涉及的外周和脊髓机制。
