Zhang Fang, Wu Luyi, Zhao Jimeng, Lv Tingting, Hu Zhihai, Weng Zhijun, Wang Shuoshuo, Wu Huangan, Liu Huirong
Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China.
Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China.
Gastroenterol Res Pract. 2017;2017:5687496. doi: 10.1155/2017/5687496. Epub 2017 Jan 24.
It is currently accepted that the neural transduction pathways of gastrointestinal (GI) visceral pain include the peripheral and central pathways. Existing research on the neurological mechanism of electroacupuncture (EA) in the treatment of GI visceral pain has primarily been concerned with the regulation of relevant transduction pathways. The generation of pain involves a series of processes, including energy transduction of stimulatory signals in the sensory nerve endings (signal transduction), subsequent conduction in primary afferent nerve fibers of dorsal root ganglia, and transmission to spinal dorsal horn neurons, the ascending transmission of sensory signals in the central nervous system, and the processing of sensory signals in the cerebral cortex. Numerous peripheral neurotransmitters, neuropeptides, and cytokines participate in the analgesic process of EA in visceral pain. Although EA has excellent efficacy in the treatment of GI visceral pain, the pathogenesis of the disease and the analgesic mechanism of the treatment have not been elucidated. In recent years, research has examined the pathogenesis of GI visceral pain and its influencing factors and has explored the neural transduction pathways of this disease.
目前公认，胃肠道（GI）内脏痛的神经传导通路包括外周和中枢通路。现有关于电针（EA）治疗GI内脏痛的神经机制研究主要关注相关传导通路的调节。疼痛的产生涉及一系列过程，包括感觉神经末梢中刺激信号的能量转换（信号转导）、随后在背根神经节的初级传入神经纤维中的传导、以及向脊髓背角神经元的传递、感觉信号在中枢神经系统中的上行传导、以及在大脑皮层中对感觉信号的处理。众多外周神经递质、神经肽和细胞因子参与了EA在内脏痛中的镇痛过程。尽管EA在治疗GI内脏痛方面具有出色的疗效，但该疾病的发病机制和治疗的镇痛机制尚未阐明。近年来，研究已经考察了GI内脏痛的发病机制及其影响因素，并探索了该疾病的神经传导通路。
