Göthberg G, Nordlander M, Lundgren Y
J Hypertens Suppl. 1986 Oct;4(3):S399-402.
The changes in peripheral haemodynamics and regional resistances were studied during the rapid fall in mean arterial pressure (MAP) after surgical reversal of two-kidney, one clip renal hypertension in rats (RHR). The controls used were sham-declipped RHR and normotensive control rats (NCR). During the 2 h following renal artery declipping or sham-operation, MAP and heart rate (HR) were followed continuously. Finally, the regional blood flows in the kidneys, small intestine and skeletal muscle were determined by the microsphere technique. Declipping caused MAP to fall from 167 +/- 5 to 108 +/- 5 mmHg (n = 10) with a concomitant fall in HR from 424 +/- 11 to 363 +/- 14 beats/min (P less than 0.01). The calculated vascular resistances fell in the intestinal and declipped renal vascular beds by 50-60% compared with sham-operated rats (P less than 0.01). However, vascular resistances remained unchanged in skeletal muscle and in the untouched kidney. This indicates that the reduction in flow resistance varies in the different vascular beds, presumably reflecting a mixture of suppressed sympathetic activity and direct vasodilatory actions induced by mechanisms activated upon reversal of two-kidney, one clip renal hypertension by renal artery declipping.
在大鼠两肾一夹肾性高血压（RHR）手术逆转后平均动脉压（MAP）快速下降期间，研究了外周血流动力学和局部阻力的变化。所用对照组为假去夹RHR大鼠和正常血压对照大鼠（NCR）。在肾动脉去夹或假手术后的2小时内，持续监测MAP和心率（HR）。最后，采用微球技术测定肾脏、小肠和骨骼肌的局部血流量。去夹导致MAP从167±5 mmHg降至108±5 mmHg（n = 10），同时HR从424±11次/分钟降至363±14次/分钟（P<0.01）。与假手术大鼠相比，计算得出的肠道和去夹肾血管床的血管阻力下降了50 - 60%（P<0.01）。然而，骨骼肌和未处理肾脏的血管阻力保持不变。这表明不同血管床的血流阻力降低情况不同，推测这反映了交感神经活动受抑制以及肾动脉去夹逆转两肾一夹肾性高血压时激活的机制所诱导的直接血管舒张作用的综合结果。
