Göthberg G, Thorén P
J Hypertens Suppl. 1984 Dec;2(3):S355-7.
The change in tonic renal efferent sympathetic nerve activity (RSNA) was studied during the rapid fall in mean arterial pressure (MAP) after surgical reversal of two-kidney, one clip hypertension in rats (RHR). Controls used were intact RHR exposed to the same fall in MAP induced by slow infusion of sodium nitroprusside. Within 2 h after declipping, MAP had fallen from 191 +/- 9 mmHg to 106 +/- 8 mmHg. During this decline in pressure, the reflex increase in RSNA, ordinarily following a decrease in pressure, was clearly suppressed; after a short and transient initial increase, RSNA was below the control level. In comparison, upon vascular dilatation with sodium-nitroprusside, the same fall in MAP was accompanied by a 117 +/- 30% increase in RSNA (P less than 0.01). Thus, the rapid normalization of MAP after reversal of renovascular hypertension involves a mechanism that exerts a suppressive action on the efferent sympathetic activity.
在大鼠双肾单夹高血压（RHR）手术逆转后平均动脉压（MAP）快速下降期间，研究了紧张性肾传出交感神经活动（RSNA）的变化。所用对照组为完整的RHR，通过缓慢输注硝普钠使其MAP出现相同程度的下降。解除夹闭后2小时内，MAP从191±9 mmHg降至106±8 mmHg。在压力下降过程中，通常随压力降低而出现的RSNA反射性增加明显受到抑制；在短暂的初始增加后，RSNA低于对照水平。相比之下，在用硝普钠进行血管扩张时，相同程度的MAP下降伴随着RSNA增加117±30%（P<0.01）。因此，肾血管性高血压逆转后MAP的快速正常化涉及一种对传出交感神经活动具有抑制作用的机制。
