一例丙型肝炎诱发的混合性冷球蛋白血症的严重病例。
A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia.
作者信息
Khalid Sameeha, Alhankawi Dhuha, Kaur Kamalmeet, Ali Ali, Kazaryan Anna, Roytman Marina
机构信息
Department of Internal Medicine, University of California San Francisco-Fresno, Fresno, CA, USA.
Department of Gastroenterology & Hepatology, University of California San Francisco-Fresno, Fresno, CA, USA.
出版信息
Case Reports Hepatol. 2021 Oct 8;2021:8244432. doi: 10.1155/2021/8244432. eCollection 2021.
Hepatitis C-induced mixed cryoglobulinemia leading to rapidly progressive gangrene, necessitating amputations, is a rare presentation. We describe a case of a 55-year-old man with untreated chronic hepatitis C virus (HCV) presenting with arthralgia and palpable purpura, which rapidly progressed to life-threatening gangrene of all extremities requiring amputations in the setting of mixed cryoglobulinemia. Treatment for HCV was initiated which led to the arrest of gangrene progression and the patient's survival. Patients with HCV-induced cryoglobulinemia should be closely monitored and started on early therapy with direct-acting antiviral therapy to prevent progression of vasculitis to gangrene. Universal screening for HCV can aid in early diagnosis and treatment to prevent devastating consequences.
丙型肝炎引起的混合性冷球蛋白血症导致快速进展性坏疽，需要截肢，这是一种罕见的表现。我们描述了一例55岁未治疗的慢性丙型肝炎病毒（HCV）感染男性患者，其表现为关节痛和可触及的紫癜，在混合性冷球蛋白血症的情况下迅速发展为危及生命的四肢坏疽，需要截肢。启动了针对HCV的治疗，这导致坏疽进展停止，患者得以存活。丙型肝炎病毒引起的冷球蛋白血症患者应密切监测，并尽早开始直接抗病毒治疗，以防止血管炎进展为坏疽。对HCV进行普遍筛查有助于早期诊断和治疗，以防止出现严重后果。
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