Jacq F, Emmerich J, Héron E, Lortholary O, Bruneval P, Fiessinger J N
Service de médecine interne, hôpital Broussais, Paris, France.
Rev Med Interne. 1997;18(4):324-7. doi: 10.1016/s0248-8663(97)84019-2.
We report the case of a 63-year old women with toe gangrene, peripheral polyneuropathy, polyarthritis, histologically proven necrotizing vasculitis, in association with type III mixed cryoglobulinemia and hepatitis C virus (HCV) infection. Raised anticardiolipin antibodies (aCL) were found, without beta 2-glycoprotein I. HCV infection is associated with mixed cryoglobulinemia which can cause a vasculitis affecting various organs. The pathogenesis of production and clinical significance of aCL could be associated in this case with HCV infection.
我们报告了一例63岁女性患者，患有趾坏疽、周围性多神经病、多关节炎，组织学证实为坏死性血管炎，同时伴有III型混合性冷球蛋白血症和丙型肝炎病毒（HCV）感染。发现抗心磷脂抗体（aCL）升高，且无β2糖蛋白I。HCV感染与混合性冷球蛋白血症相关，后者可导致影响多个器官的血管炎。在该病例中，aCL产生的发病机制及临床意义可能与HCV感染有关。
