与丙型肝炎病毒感染相关的伴有抗心磷脂抗体的远端坏疽和冷球蛋白血症

[Distal gangrene and cryoglobulinemia related to hepatitis C virus infection with presence of anticardiolipin antibodies].

作者信息

Jacq F, Emmerich J, Héron E, Lortholary O, Bruneval P, Fiessinger J N

机构信息

Service de médecine interne, hôpital Broussais, Paris, France.

出版信息

Rev Med Interne. 1997;18(4):324-7. doi: 10.1016/s0248-8663(97)84019-2.

DOI:10.1016/s0248-8663(97)84019-2

PMID:9161561

Abstract

We report the case of a 63-year old women with toe gangrene, peripheral polyneuropathy, polyarthritis, histologically proven necrotizing vasculitis, in association with type III mixed cryoglobulinemia and hepatitis C virus (HCV) infection. Raised anticardiolipin antibodies (aCL) were found, without beta 2-glycoprotein I. HCV infection is associated with mixed cryoglobulinemia which can cause a vasculitis affecting various organs. The pathogenesis of production and clinical significance of aCL could be associated in this case with HCV infection.

摘要

我们报告了一例63岁女性患者，患有趾坏疽、周围性多神经病、多关节炎，组织学证实为坏死性血管炎，同时伴有III型混合性冷球蛋白血症和丙型肝炎病毒（HCV）感染。发现抗心磷脂抗体（aCL）升高，且无β2糖蛋白I。HCV感染与混合性冷球蛋白血症相关，后者可导致影响多个器官的血管炎。在该病例中，aCL产生的发病机制及临床意义可能与HCV感染有关。