原发性混合性冷球蛋白血症。丙型肝炎病毒感染与未感染患者皮肤表现的比较研究。

Essential mixed cryoglobulinemia. A comparative study of dermatologic manifestations in patients infected or noninfected with hepatitis C virus.

作者信息

Dupin N, Chosidow O, Lunel F, Cacoub P, Musset L, Cresta P, Frangeul L, Piette J C, Godeau P, Opolon P

机构信息

Department of Bacteriology and Virology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

出版信息

Arch Dermatol. 1995 Oct;131(10):1124-7. doi: 10.1001/archderm.131.10.1124.

DOI:10.1001/archderm.131.10.1124

PMID:7574827

Abstract

BACKGROUND AND DESIGN

An association between essential mixed cryoglobulinemia and hepatitis C virus (HCV) infection has been reported. Dermatologic manifestations are a classic presenting complaint in essential mixed cryoglobulinemia. The aim of this study was to compare the frequency and the nature of dermatologic manifestations in essential mixed cryoglobulinemia according to the presence of anti-HCV antibodies. Sixty-two consecutive patients with essential mixed cryoglobulinemia were tested for anti-HCV antibodies. Dermatologic manifestations were systematically assessed.

RESULTS

Anti-HCV antibodies were detected in 35 patients. Palpable purpura corresponding histologically to leukocytoclastic vasculitis was the more frequently observed dermatologic manifestation and occurred mainly in HCV-antibody-positive patients. The patients with purpura had significantly higher serum cryoglobulin levels than patients without purpura.

CONCLUSIONS

The frequency of palpable purpura is higher in HCV-antibody-positive patients and is related to the serum cryoglobulin levels.

摘要

背景与设计

已有报道称特发性混合型冷球蛋白血症与丙型肝炎病毒（HCV）感染之间存在关联。皮肤表现是特发性混合型冷球蛋白血症的典型主诉。本研究的目的是根据抗HCV抗体的存在情况，比较特发性混合型冷球蛋白血症中皮肤表现的频率和性质。对62例连续性特发性混合型冷球蛋白血症患者进行了抗HCV抗体检测，并系统评估了皮肤表现。