Bin Waqar Syed Hamza, Zaman Unaiza, Salahi Navid, Gupta Raavi, McFarlane Isabel M
Internal Medicine, State University of New York Downstate Medical Center, New York, USA.
Pathology, State University of New York Downstate Medical Center, New York, USA.
Cureus. 2021 Sep 6;13(9):e17766. doi: 10.7759/cureus.17766. eCollection 2021 Sep.
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is one of the rarest forms of primary cutaneous lymphomas (PCLs) and it confers a poor prognosis. Diagnosis of PCDLBCL-LT can be challenging and complex as it can manifest with a myriad of dermatological presentations. However, early treatment with chemo-radiation leads to an appropriate response. We present the case of a 66-year-old female with a history of polymyositis and interstitial lung disease on immunosuppression who presented to our institution with recurrent abscess-like lesions localized to buttocks that were later biopsied and diagnosed as the leg-type variant of PCL. She received chemotherapy with the rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen and subsequent involved-site radiation therapy (ISRT), which resulted in complete remission. The patient was later followed up and remained in remission for years.
原发性皮肤弥漫性大B细胞淋巴瘤，腿部型（PCDLBCL-LT）是原发性皮肤淋巴瘤（PCL）中最罕见的形式之一，预后较差。PCDLBCL-LT的诊断具有挑战性且复杂，因为它可表现为多种皮肤病学表现。然而，早期进行放化疗可带来适当的反应。我们报告一例66岁女性病例，该患者有皮肌炎和间质性肺病病史，正在接受免疫抑制治疗，因臀部反复出现脓肿样病变前来我院就诊，这些病变后来经活检被诊断为腿部型PCL。她接受了利妥昔单抗联合环磷酰胺、多柔比星、长春新碱和泼尼松（R-CHOP）方案的化疗以及随后的受累部位放射治疗（ISRT），结果实现了完全缓解。该患者随后接受随访，多年来一直处于缓解状态。
