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异步复制时间：发育过程中单等位基因选择的一种机制。

Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development.

作者信息

Bergman Yehudit, Simon Itamar, Cedar Howard

机构信息

Department of Developmental Biology and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel.

Department of Microbiology and Molecular Genetics, Hebrew University Hadassah Medical School, The Institute for Medical Research Israel-Canada (IMRIC), Jerusalem, Israel.

出版信息

Front Cell Dev Biol. 2021 Oct 1;9:737681. doi: 10.3389/fcell.2021.737681. eCollection 2021.

DOI:10.3389/fcell.2021.737681
PMID:34660595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8517340/
Abstract

Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.

摘要

发育编程是通过一系列分子选择来进行的，这些选择在表观遗传上标记基因组，以产生构成整个生物体的稳定细胞类型。许多重要过程，如基因组印记、免疫或嗅觉受体的选择以及雌性个体中的X染色体失活，都依赖于在每个细胞中稳定选择单个等位基因的能力。从这个角度来看，我们提出异步复制时间（ASRT）作为一种复杂的通用机制的基础，用于介导和维持这些决定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/8b7066b60d8c/fcell-09-737681-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/c887e1bf96f2/fcell-09-737681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/2cc79aabbf6b/fcell-09-737681-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/529e4fbee548/fcell-09-737681-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/8b7066b60d8c/fcell-09-737681-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/c887e1bf96f2/fcell-09-737681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/2cc79aabbf6b/fcell-09-737681-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/529e4fbee548/fcell-09-737681-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/8517340/8b7066b60d8c/fcell-09-737681-g004.jpg

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本文引用的文献

1
Features and mechanisms of canonical and noncanonical genomic imprinting.经典和非经典基因组印迹的特征和机制。
Genes Dev. 2021 Jun;35(11-12):821-834. doi: 10.1101/gad.348422.121.
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Replication timing maintains the global epigenetic state in human cells.复制时间维持着人类细胞的全局表观遗传状态。
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Chromosomal coordination and differential structure of asynchronous replicating regions.染色体协调与异步复制区的差异结构。
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Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication.活跃和被抑制的染色质结构域在 DNA 复制过程中表现出不同的核小体分离。
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Control of DNA replication timing in the 3D genome.三维基因组中 DNA 复制时间的控制。
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Frequent monoallelic or skewed expression for developmental genes in CNS-derived cells and evidence for balancing selection.中枢神经系统来源的细胞中发育基因的频繁单等位基因或偏性表达，并存在平衡选择的证据。
Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10379-E10386. doi: 10.1073/pnas.1808652115. Epub 2018 Oct 15.
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X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation.X 染色体失活：染色体结构与基因调控的交汇点。
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