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经典和非经典基因组印迹的特征和机制。

Features and mechanisms of canonical and noncanonical genomic imprinting.

机构信息

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom.

Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, United Kingdom.

出版信息

Genes Dev. 2021 Jun;35(11-12):821-834. doi: 10.1101/gad.348422.121.

DOI:10.1101/gad.348422.121
PMID:34074696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8168557/
Abstract

Genomic imprinting is the monoallelic expression of a gene based on parent of origin and is a consequence of differential epigenetic marking between the male and female germlines. Canonically, genomic imprinting is mediated by allelic DNA methylation. However, recently it has been shown that maternal H3K27me3 can result in DNA methylation-independent imprinting, termed "noncanonical imprinting." In this review, we compare and contrast what is currently known about the underlying mechanisms, the role of endogenous retroviral elements, and the conservation of canonical and noncanonical genomic imprinting.

摘要

基因组印记是基于亲源的基因单等位基因表达，是雌雄生殖系之间差异表观遗传标记的结果。通常，基因组印记是由等位基因 DNA 甲基化介导的。然而，最近已经表明，母体 H3K27me3 可以导致 DNA 甲基化非依赖性印记，称为“非典型印记”。在这篇综述中，我们比较和对比了目前已知的关于潜在机制、内源性逆转录病毒元件的作用以及经典和非经典基因组印记的保守性的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/307d/8168557/5b176212a731/821f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/307d/8168557/ed07db76aecf/821f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/307d/8168557/4136e1f3e156/821f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/307d/8168557/5b176212a731/821f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/307d/8168557/ed07db76aecf/821f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/307d/8168557/4136e1f3e156/821f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/307d/8168557/5b176212a731/821f03.jpg

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Nat Genet. 2021 Apr;53(4):551-563. doi: 10.1038/s41588-021-00821-2. Epub 2021 Apr 5.
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Epigenetics Chromatin. 2025 Apr 5;18(1):19. doi: 10.1186/s13072-025-00583-9.
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