Huang Danqing, Cui Cunying, Zheng Qiang, Li Yanan, Liu Yuanyuan, Hu Yanbin, Wang Ying, Liu Ruijie, Liu Lin
Department of Ultrasound, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
School of Computer and Control Engineering, Yantai University, Yantai, China.
Front Cardiovasc Med. 2021 Oct 1;8:733339. doi: 10.3389/fcvm.2021.733339. eCollection 2021.
Type 2 diabetes mellitus (T2DM) is a common risk factor for cardiovascular diseases. The aims of this study were to evaluate the changes in the left ventricular myocardial work in T2DM patients using the left ventricular pressure-strain loop (PSL) technique, and to explore the risk factors for the left ventricular myocardial work impairment. Fifty patients with T2DM and 50 normal controls (NCs) were included in the study. In addition to conventional echocardiography and two-dimensional speckle tracking echocardiography, the left ventricular myocardial work parameters were measured using PSL technology. The absolute value for global longitudinal strain (GLS), global work index (GWI) and, global constructive work (GCW) were significantly decreased in the T2DM group ( < 0.05), while the left ventricular ejection fraction (LVEF) was not significantly different between the T2DM and NC groups. Multivariable linear regression analysis showed that hemoglobin A1c (HbA1c) was independently related to GWI (β = -0.452, < 0.05), while HbA1c and the diabetes duration were independently related to GCW (β = -0.393, < 0.05 and β = -0.298, < 0.05, respectively). Changes in the left ventricular myocardial systolic function in T2DM patients were identified using PSL technology. HbA1c was shown to be an independent risk factor affecting GWI, while HbA1c and diabetes duration were demonstrated to be independent risk factors affecting GCW.
2型糖尿病（T2DM）是心血管疾病的常见危险因素。本研究的目的是使用左心室压力-应变环（PSL）技术评估T2DM患者左心室心肌做功的变化，并探讨左心室心肌做功受损的危险因素。本研究纳入了50例T2DM患者和50例正常对照（NC）。除了常规超声心动图和二维斑点追踪超声心动图外，还使用PSL技术测量左心室心肌做功参数。T2DM组的整体纵向应变（GLS）绝对值、整体做功指数（GWI）和整体建设性做功（GCW）均显著降低（<0.05），而T2DM组和NC组之间的左心室射血分数（LVEF）无显著差异。多变量线性回归分析显示，糖化血红蛋白（HbA1c）与GWI独立相关（β=-0.452，<0.05），而HbA1c和糖尿病病程与GCW独立相关（分别为β=-0.393，<0.05和β=-0.298，<0.05）。使用PSL技术确定了T2DM患者左心室心肌收缩功能的变化。HbA1c被证明是影响GWI的独立危险因素，而HbA1c和糖尿病病程被证明是影响GCW的独立危险因素。
