Likhitkar Sweta, Bajpai A K
Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, MP 482003, India.
Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, MP 482003, India.
Carbohydr Polym. 2012 Jan 4;87(1):300-308. doi: 10.1016/j.carbpol.2011.07.053. Epub 2011 Aug 3.
The present study involves a novel strategy for the preparation of superparamagnetic nanoparticles of crosslinked starch impregnated with homogeneously dispersed nanosized iron oxide. The nanoparticles were loaded with an anticancer drug 'cisplatin' and the drug release kinetics was investigated spectrophotometrically at physiological pH (7.4). The nanoparticles were characterized by Fourier transform infra red (FTIR) spectroscopy, transmission electron microscopy (TEM), X-ray diffraction and magnetization studies. The particle size of magnetic starch nanoparticles was found to lie in the range of 20-90nm. The influence of factors like chemical composition of nanoparticles, pH and temperature of the release media and applied magnetic field was investigated on the release profiles of the drug. The prepared nanoparticles could provide a possible pathway for targeted and controlled delivery of anticancer drugs minimizing side effects and achieving higher efficacy.
本研究涉及一种制备交联淀粉超顺磁性纳米颗粒的新策略，该颗粒浸渍有均匀分散的纳米级氧化铁。纳米颗粒负载了抗癌药物“顺铂”，并在生理pH值（7.4）下通过分光光度法研究了药物释放动力学。通过傅里叶变换红外（FTIR）光谱、透射电子显微镜（TEM）、X射线衍射和磁化研究对纳米颗粒进行了表征。发现磁性淀粉纳米颗粒的粒径在20-90nm范围内。研究了纳米颗粒的化学成分、释放介质的pH值和温度以及外加磁场等因素对药物释放曲线的影响。所制备的纳米颗粒可为抗癌药物的靶向和控释提供一条可能的途径，从而将副作用降至最低并实现更高的疗效。
