Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, 482001, MP, India.
J Mater Sci Mater Med. 2011 Feb;22(2):357-69. doi: 10.1007/s10856-010-4214-2. Epub 2010 Dec 29.
Polymer nanocomposites exhibiting superparamagnetic behavior have been recognized as a promising tool to achieve targeted drug delivery using external magnetic field for treating complex diseases like cancers and tumors. The present investigation attempts to design a superparamagnetic nanocomposite which could desirably deliver ciprofloxacin drug by application of varying magnetic field. In order to achieve the proposed objectives, a polymer matrix of polyvinyl alcohol-g-polymethyl methacrylate was prepared by free radical polymerization and iron oxide particles were impregnated by in situ precipitation method. The prepared nanocomposites were characterized by techniques like FTIR, electron microscopy (SEM and TEM) and XRD and magnetization studies were performed to ensure superparamagnetic behavior. The antibiotic drug ciprofloxacin was loaded onto the magnetic nanocomposites and the influence of various factors such as percent loading, chemical composition of the nanocomposite, applied magnetic field, pH of the release medium were investigated on the release profiles of the drug. The chemical integrity of the drug and its antibacterial potential were also studied. The dynamics of the release process was also examined mechanistically.
表现出超顺磁性的聚合物纳米复合材料已被认为是一种很有前途的工具，可利用外部磁场实现靶向药物输送，用于治疗癌症和肿瘤等复杂疾病。本研究旨在设计一种超顺磁纳米复合材料，通过施加不同的磁场来理想地输送环丙沙星药物。为了实现提出的目标，通过自由基聚合制备了聚乙烯醇-g-聚甲基丙烯酸甲酯的聚合物基质，并通过原位沉淀法浸渍了氧化铁颗粒。通过傅里叶变换红外光谱（FTIR）、电子显微镜（SEM 和 TEM）和 X 射线衍射（XRD）等技术对制备的纳米复合材料进行了表征，并进行了磁化研究以确保超顺磁性。将抗生素药物环丙沙星负载到磁性纳米复合材料上，并研究了各种因素，如载药量、纳米复合材料的化学成分、施加的磁场、释放介质的 pH 值对药物释放曲线的影响。还研究了药物的化学完整性及其抗菌潜力。还从机械上研究了释放过程的动力学。
