Laboratorio de Medicina Traslacional, Escuela Superior de Medicina, Instituto Politecnico Nacional, Salvador Díaz Mirón esq. Plan de San Luis S/N, Miguel Hidalgo, Casco de Santo Tomas, 11340, Mexico, CDMX, Mexico.
Laboratorio de Biología Molecular, Laboratorio Estatal de Salud Pública del Estado de México, Tollocan S/N Colonia Moderna de la Cruz, 50180, Toluca,, Mexico.
BMC Infect Dis. 2021 Oct 18;21(1):1072. doi: 10.1186/s12879-021-06765-6.
COVID-19 cases have been increasing since the epidemic started. One of the major concerns is how clinical symptomatology would behave after coinfection with another virus.
In this case report, a pediatric native patient from Estado de Mexico (EDOMEX), MEX had severe DENV-2 and acute SARS-CoV-2 at the same time. The clinical features were severe thrombocytopenia, secondary septic shock, cerebral edema, pericardial effusion, fluid overload that exhibited bipalpebral edema in all four extremities, hemophagocytic lymphohistiocytosis (HLH), coronary artery ectasia (CAE), multisystemic inflammatory syndrome in children (MIS-C), and probable COVID-19 pneumonia or acute respiratory distress syndrome (ARDS) that triggered patient intubation. The patient presented unusual symptomatology according to the literature. After 15 days of intubation and 15 more days under surveillance, he was released without respiratory sequelae and without treatment after major clinical improvement.
The aim of this manuscript is to present clinical challenges that coinfection may cause in pediatric patients, even though COVID-19 in children does not tend to be as severe as in other sectors of the population.
自疫情开始以来，COVID-19 病例一直在增加。人们主要关注的问题之一是在同时感染另一种病毒后，临床症状会如何表现。
在本病例报告中，来自墨西哥州（EDOMEX）的一名儿科本地患者同时患有严重的登革热病毒 2 型（DENV-2）和急性严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）感染。临床特征为严重血小板减少症、继发感染性休克、脑水肿、心包积液、四肢均出现双眼睑水肿的液体超负荷、噬血细胞性淋巴组织细胞增生症（HLH）、冠状动脉扩张（CAE）、儿童多系统炎症综合征（MIS-C）以及可能的 COVID-19 肺炎或急性呼吸窘迫综合征（ARDS），这些病症导致患者需要插管。该患者表现出了与文献报道不同的异常症状。经过 15 天的插管和 15 天的监测，患者在主要临床症状改善后，未出现呼吸后遗症且无需治疗即出院。
本文旨在介绍儿童患者同时感染可能带来的临床挑战，尽管儿童感染 COVID-19 的严重程度不如其他人群。
