线粒体与血液肿瘤的肿瘤微环境。

Mitochondria and the Tumour Microenvironment in Blood Cancer.

机构信息

Department of Molecular Haematology, Norwich Medical School, University of East Anglia, Norwich, UK.

Earlham Institute, Norwich, UK.

出版信息

Adv Exp Med Biol. 2021;1329:181-203. doi: 10.1007/978-3-030-73119-9_10.

DOI:10.1007/978-3-030-73119-9_10

PMID:34664240

Abstract

The bone marrow (BM) is a complex organ located within the cavities of bones. The main function of the BM is to produce all the blood cells required for a normal healthy blood system. As with any major organ, many diseases can arise from errors in bone marrow function, including non-malignant disorders such as anaemia and malignant disorders such as leukaemias. This article will explore the role of the bone marrow, in normal and diseased haematopoiesis, with an emphasis on the requirement for intercellular mitochondrial transfer in leukaemia.

摘要

骨髓（BM）是位于骨腔中的一个复杂器官。BM 的主要功能是产生正常健康血液系统所需的所有血细胞。与任何主要器官一样，许多疾病都可能源于骨髓功能的错误，包括非恶性疾病如贫血和恶性疾病如白血病。本文将探讨骨髓在正常和病态造血中的作用，重点强调白血病中细胞间线粒体转移的要求。