细胞外囊泡介导的血液系统肿瘤细胞间通讯。
Extracellular vesicle-mediated cell-cell communication in haematological neoplasms.
机构信息
Department of Molecular Oncology, Institute of Medical Science, Tokyo, Japan
Department of Molecular Oncology, Institute of Medical Science, Tokyo, Japan.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). doi: 10.1098/rstb.2016.0484.
Crosstalk between bone marrow tumour cells and surrounding cells, including bone marrow mesenchymal stromal cells (BM-MSCs), endothelial cells and immune cells, is important for tumour growth in haematological neoplasms. In addition to conventional signalling pathways, extracellular vesicles (EVs), which are endosome-derived vesicles containing proteins, mRNAs, lipids and miRNAs, can facilitate modulation of the bone marrow microenvironment without directly contacting non-tumourous cells. In this review, we discuss the current understanding of EV-mediated cell-cell communication in haematological neoplasms, particularly leukaemia and multiple myeloma. We highlight the actions of tumour and BM-MSC EVs in multiple myeloma. The origin of EVs, their tropism and mechanism of EV transfer are emerging issues that need to be addressed in EV-mediated cell-cell communication in haematological neoplasms.This article is part of the discussion meeting issue 'Extracellular vesicles and the tumour microenvironment'.
骨髓肿瘤细胞与周围细胞（包括骨髓间充质基质细胞 [BM-MSCs]、内皮细胞和免疫细胞）之间的串扰对于血液肿瘤中的肿瘤生长很重要。除了传统的信号通路外，细胞外囊泡（EVs）是由内体衍生的囊泡，包含蛋白质、mRNA、脂质和 miRNAs，可以在不直接接触非肿瘤细胞的情况下调节骨髓微环境。在这篇综述中，我们讨论了目前对血液肿瘤（尤其是白血病和多发性骨髓瘤）中 EV 介导的细胞间通讯的理解。我们强调了肿瘤和 BM-MSC EVs 在多发性骨髓瘤中的作用。EV 的起源、归巢和 EV 转移的机制是血液肿瘤中 EV 介导的细胞间通讯中需要解决的新兴问题。本文是“细胞外囊泡与肿瘤微环境”讨论专题的一部分。
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