Laboratory of Biology, Tumour and Development, GIGA-Cancer, University of Liège, Institute of Pathology B23, Liège, Belgium.
Adv Exp Med Biol. 2021;1329:499-533. doi: 10.1007/978-3-030-73119-9_23.
Cancers are heterogeneous multifactorial diseases consisting of a major public health issue worldwide. Sex disparities are evidenced in cancer incidence, mortality, expression of prognosis factor, response to treatment, and survival. For both sexes, an interplay of intrinsic and environmental factors influences cancer cells and tumor microenvironment (TME) components. The TME cumulates both supportive and communicative functions, contributing to cancer development, progression, and metastasis dissemination. The frontline topics of this chapter are focused on the contribution of sex, via steroid hormones, such as estrogens and androgens, on the following components of the TME: cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), blood and lymphatic endothelial cells, and immunity/inflammatory system.
癌症是一种异质性多因素疾病，是全球主要的公共卫生问题。在癌症发病率、死亡率、预后因素表达、治疗反应和生存方面存在性别差异。对于男性和女性，内在和环境因素的相互作用影响癌细胞和肿瘤微环境（TME）成分。TME 累积了支持和通信功能，有助于癌症的发展、进展和转移扩散。本章的前沿主题集中在通过类固醇激素（如雌激素和雄激素）对 TME 的以下成分的贡献：癌症相关成纤维细胞（CAF）、细胞外基质（ECM）、血液和淋巴内皮细胞以及免疫/炎症系统。
