Carvalho-Silva Larissa Tinô de, Normando Ana Gabriela C, Sá Jamile de Oliveira, Dos Santos Erison Santana, De Rossi Tatiane, Busso-Lopes Ariane Fidelis, de Oliveira Ana Karina, Paes Leme Adriana F
Laboratório Nacional de Biociências - LNBio, Centro Nacional de Pesquisa em Energia e Materiais - CNPEM, Campinas, SP 13083-100, Brazil.
Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba Universidade Estadual de Campinas (UNICAMP), Piracicaba, SP 13414-903, Brazil.
Biochem Soc Trans. 2023 Apr 26;51(2):771-781. doi: 10.1042/BST20221175.
Cancer is a significant cause of death, precluding increasing life expectancy worldwide. That is a multifactorial disease initiated by intrinsic or extrinsic factors that induce cell differentiation into cancer cells. However, cancer development, progression, and metastasis are not controlled only by cancer cells. The entire environment around these cells, named tumor microenvironment (TME), influences tumor development and spread. The tumor microenvironment is formed by cancer cells and heterogenous nonmalignant cells integrated with a complex extracellular matrix. The main cellular components of the TME are cancer-associated fibroblasts (CAFs), T lymphocytes, B cells, tumor-associated macrophages (TAMs), dendritic cells (DC), natural killer (NK) cells, tumor-associated neutrophils (TANs), Stem Cells, Endothelial Cells and their soluble secreted extracellular vesicles (EVs) that modulate cancer cells to establish and disseminate. This review provides a recent insight into the role of EVs secreted from different populations of the TME associated with the initiation and progression of carcinoma.
癌症是导致死亡的一个重要原因，阻碍了全球预期寿命的提高。癌症是一种多因素疾病，由内在或外在因素引发，这些因素会诱导细胞分化为癌细胞。然而，癌症的发生、发展和转移并非仅由癌细胞控制。这些细胞周围的整个环境，即肿瘤微环境（TME），会影响肿瘤的发展和扩散。肿瘤微环境由癌细胞和与复杂细胞外基质整合的异质性非恶性细胞组成。肿瘤微环境的主要细胞成分是癌症相关成纤维细胞（CAF）、T淋巴细胞、B细胞、肿瘤相关巨噬细胞（TAM）、树突状细胞（DC）、自然杀伤（NK）细胞、肿瘤相关中性粒细胞（TAN）、干细胞、内皮细胞及其分泌的可溶性细胞外囊泡（EV），这些成分可调节癌细胞的形成和扩散。本综述提供了对肿瘤微环境中不同群体分泌的细胞外囊泡在癌症发生和发展过程中所起作用的最新见解。
