Liang Aihong, Huang Lan'e, Liu Huiqing, He Weiguo, Lei Xiaocan, Li Meixiang, Li Suyun, Liang Hongxing, Chen Gang, Tang Jinru, Chen Fengyu, Cao Xiting, Wang Yiyao, Shen Xiaobu, Chen Xi
Hunan Province Innovative Training Base for Medical Postgraduates, Hengyang Medical School, University of South China and Yueyang Women & Children's Medical Center, Yueyang, Hunan, 416000, China.
Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Mol Nutr Food Res. 2021 Dec;65(24):e2100457. doi: 10.1002/mnfr.202100457. Epub 2021 Nov 1.
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that can cause infertility; however, the underlying mechanisms remain ill-defined, and there are no available drugs or strategies for the treatment of PCOS. This study examined the therapeutic effect of resveratrol in a rat model of PCOS.
PCOS is induced in rats by administration of letrozole and a high fat diet to determine whether resveratrol has a protective effect. Oral administration of resveratrol significantly decreased body weight, as well as the serum levels of testosterone and follicle stimulating hormone. Resveratrol improved the estrous cycle by restoring the thickness and number of granular cells. Resveratrol increased the levels of lactate and ATP, decreased pyruvate levels, and restored the glycolytic process, upregulating LDHA, HK2, and PKM2. Resveratrol also upregulated SIRT2, thereby modulating the expression of rate-limiting enzymes of glycolysis.
Resveratrol suppressed damage to the ovaries in PCOS rats by restoring glycolytic activity, providing potential targets for the treatment of PCOS.
多囊卵巢综合征（PCOS）是一种常见的内分泌和代谢紊乱疾病，可导致不孕；然而，其潜在机制仍不明确，且尚无治疗PCOS的可用药物或策略。本研究考察了白藜芦醇在PCOS大鼠模型中的治疗效果。
通过给大鼠施用来曲唑和高脂饮食诱导PCOS，以确定白藜芦醇是否具有保护作用。口服白藜芦醇可显著降低体重以及血清睾酮和促卵泡激素水平。白藜芦醇通过恢复颗粒细胞的厚度和数量改善发情周期。白藜芦醇增加乳酸和ATP水平，降低丙酮酸水平，并恢复糖酵解过程，上调LDHA、HK2和PKM2。白藜芦醇还上调SIRT2，从而调节糖酵解限速酶的表达。
白藜芦醇通过恢复糖酵解活性抑制PCOS大鼠卵巢损伤，为PCOS的治疗提供了潜在靶点。
